Druggist Menu
Post Highlights

Armodafinil vs. Modafinil: Which Is Effective For You?

armodafinil-vs-modafinil

It is estimated that 22 million Americans suffer from sleeping issues, including sleep apnea. If you struggle with sleepiness from a night shift’s work or other issues, Armodafinil and Modafinil can help you stay awake. With a doctor’s prescription, you can get these medications with a doctor’s prescription. Both Armodafinil and Modafinil are manufactured by Cephalon Inc., a subsidiary of Teva Pharmaceutical Industries Ltd. Modafinil was approved by the FDA in December 1998. On the other hand, Armodafinil was approved by the FDA in June 2007.

Armodafinil is an enantiopure compound of the eugeroic Modafinil sold under the brand name Nuvigil. This medication belongs to the stimulants class of drugs which are primarily used to reduce excessive sleepiness and promote wakefulness.

Modafinil is an FDA-approved drug sold under the brand name Provigil. The medication belongs to the stimulants class of drugs and is used to treat sleep conditions. The active ingredients in this medication are croscarmellose sodium, lactose monohydrate, microcrystalline cellulose, pregelatinized starch, and povidone.

Age Restrictions

Armodafinil and Modafinil are not advised to be consumed by anyone below 17 years. Consult your doctor and follow the instructions and the prescription accordingly.

What Can These Medications Treat?

Armodafinil and Modanifil treat conditions such as narcolepsy, obstructive sleep apnea, shift work sleep disorder, or other sleep disorders. The medications lead to wakefulness by preventing extreme sleepiness. However, these medications do not treat insomnia.

Quick FAQ

Can Modafinil cure depression?
Modafinil can improve mood and reduce the remission rate of depression.

Availability and Cost

Armodafinil

Availability: Armodafinil is available in both the UK and the US under the brand name Nuvigil.

Cost: Armodafinil is sold in the UK for £8.31 per 150 mg tablet. In the US, it is about $6.88 per 150 mg tablet.

Modafinil

Availability: Modafinil is available in both UK and USA.

Cost: Modafinil costs about $10.51 per 200 mg tablet in the US. It is around £8.32 per 200 mg tablet in the UK.

Armodafinil and Modafinil : Forms and Dosage 

Form: Armodafinil is available in tablets in the strengths of 50 mg, 150 mg, 200 mg, 250 mg.

Dosage:

Adult dosage for Obstructive Sleep Apnea/Hypopnea Syndrome:

  • The recommended dosage is about 150-250 mg orally in the morning.

Adult dosage for Shift Work Sleep Disorder

  • The recommended dosage is 150 mg orally once a day, 1 hour before starting the work shift.

Form: Modafinil is available as oral tablets of 100 mg and 200 mg.

Dosage:

Adult dosage for Obstructive Sleep Apnea/Hypopnea Syndrome:

  • The recommended dosage is 200 mg orally once in the morning.

Adult Shift Work Sleep Disorder:

  • The recommended dosage is 200 mg orally once a day, 1 hour before starting the work shift.

Armodafinil and Modafinil : OTC and Prescriptions

Armodafinil and Modafinil are both FDA-approved medications available as prescription-only drugs and are not sold over the counter in both UK and USA.

Mechanism of Action

Armodafinil is a medication that works by changing the levels of naturally occurring chemical substances occurring in the brain area that controls sleepiness. Armodafinil is a single isomer of Modafinil. Armodafinil is a stimulant that provides long-lasting mental arousal. Armodafinil does not directly or indirectly affect dopamine levels. The drug binds to dopamine transporters preventing dopamine reuptake.

Modafinil is the drug that works by increasing the levels of dopamine present in the brain by lowering dopamine reuptake. Modafinil tends to bind to dopamine transporters resulting in the prevention of dopamine reuptake. It stimulates glutamatergic circuits while inhibiting GABA.

Armodafinil and Modafinil: How to Take Them?

Armodafinil is a medication that can be taken orally with or without food as prescribed by your doctor for sleep conditions such as narcolepsy, shift work sleep disorder, and other related issues. Take the medication according to your doctor’s instructions.

Modafinil is a medication taken orally once a day to treat narcolepsy or obstructive sleep apnea. It is advised to take this drug in the morning. In the case of shift work sleep disorder, take the medication an hour before starting work.

Possible Side Effects Of Armodafinil and Modafinil

Armodafinil and Modafinil have both common and adverse side effects. It is important to follow your physician’s instructions to avoid these effects. The side effects are as follows:

Armodafinil Common Side effects:

These common side effects may or may not occur and usually resolve in a few days. If not, contact yours as soon as possible. The common side effects are namely:

  • Dizziness or drowsiness
  • Headaches
  • Less salivation or dry mouth
  • Constipation or diarrhea

Armodafinil Adverse side effects: 

Side effects can also be severe. Hence, it is essential to contact your doctor as soon as possible. The adverse side effects are namely:

  • Insomnia
  • Tingling sensation or numbness
  • Difficulty in breathing
  • Lack of concentration
  • Muscle weakness
  • Bleeding gums or nose bleeds

The side effects in taking this medication can be common and severe. Remember to always follow the instructions given by your doctor.

Modafinil Common side effects:

These side effects may fade away in a few days; if not, confab with a doctor as fast as possible.

  • Acid reflux or gas
  • Headaches
  • Dizziness or drowsiness
  • Constipation
  • Nausea

Modafinil Adverse side effects:

These side effects can lead to severe issues. Contact your doctor as soon as possible if you come across these in any situation when taking Modafinil:

  • Mood swings
  • Depression
  • Blurred vision
  • Memory loss
  • High blood pressure

 Armodafinil and Modafinil: Drug interactions

Armodafinil can interact with several other drugs, which can be harmful. Take the medication as directed and consult your doctor regarding medical history or allergies to avoid side effects. Here are a few drug examples that interact with Armodafinil:

  • Isocarboxazid
  • Linezolid
  • Ombitasvir/paritaprevir/ritonavir
  • Selegiline transdermal
  • Tranylcypromine

Modafinil also can interact with other drugs. It is not recommended to use this drug without a doctor’s approval. Take all the medications as directed and consult your doctor regarding any allergies to avoid any side effects. Here are a few drug examples that interact with Modafinil:

  • Avacopan
  • Mobocertinib
  • Fexinidazole
  • Finerenone
  • Voclosporin
  • Lurbinectedin

Armodafinil: Drug Warnings

Do not consume this medication if undergoing the following conditions

  • Allergic to Armodafinil
  • Any liver or kidney related issues
  • High blood pressure
  • Any history of heart-related issues such as heart attack
  • A history of mental health conditions such as depression and anxiety
  • Severe chest pain
  • Any drug addiction or history of alcohol abuse
  • Do not take the medication if you have any allergies, rashes, or bleeding.
  • Don’t forget to consult your doctor regarding these issues prior to consuming Armodanifil.

Modafinil: Drug Warnings

It is not advisable to consume the medication if suffering from the following conditions:

  • Allergic reactions to Modafinil
  • History or currently facing any heart, kidney, or liver issues
  • Mental health issues such as suicidal thoughts, depression, or anxiety
  • Any drug or alcohol addiction
  • It is not yet assured whether this medication can or cannot be taken during pregnancy, although in any case, consume the medication only as directed.
  • This medication can lead to skin allergies or rashes. So, it is not advisable to take this medication if suffering from any allergies, hives, bleeding, or blisters.
  • Don’t forget to consult your doctor regarding these issues prior to consuming Modanifil.

Armodafinil vs Modafinil: Which Is More Effective

  • A study conducted by Clinical Pharmacology Department, Cephalon, Inc., Frazer, Pennsylvania, examined both the medicines, which detected that Armodafinil was much more effective for excessive sleepiness than in comparison to Modafinil.
  • This evidence proves that Armodafinil has more efficacy as compared to Modafinil as Armodafinil has shown higher plasma concentration which triggers wakefulness.
  • However, some studies have also shown that Modafinil can be effective for tiredness and fatigue and effective during cancer treatment.

Difference Between Armodafinil and Modafinil

Drug Name Brand Name Effectiveness Dosage Chemical Form
Armodafinil Nuvigil Armodafinil is considered to be a stronger drug with efficient vigilance 150 mg once a day Enantiopure form of Modafinil
Modafinil Provigil Modafinil is considered to be comparatively less effective than Armodafinil 200 mg once a day Original drug

Similarity Between Armodafinil and Modafinil

Drug Name Drug Class Drug Form Treatment Type Who can take it?
Armodafinil CNS Stimulant Taken orally Long-lasting treatment Anyone 17 years old and above
Modafinil CNS Stimulant Taken orally Long-lasting treatment Anyone 17 years old and above

Conclusion :

Both Armodafinil and Modafinil are medications that cure sleepiness and promote wakefulness. However, before taking this medication, remember to consume it according to the prescription. Consult your doctor regarding any history or past allergies and take these medications with proper precautions.

Quick FAQ

Can Modafinil lead to euphoria or high feeling?
This medication is considered to have significantly fewer chances of abuse, although it can lead to euphoric or high feelings.
How does Armodafinil make you feel?
Armodafinil can lead to wakefulness and changes to focus, attention and reflexes.
References