Best Over The Counter Sleeping Pills UK

Best Over The Counter Sleeping Pills UK

Everyone needs a peaceful sleep, and when you do not get it due to any reason leads to a sleep disorder. Know the best sleeping pills that you can get Over the counter.

September 08, 2020

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Post Highlights

Insomnia is a common sleep disorder characterized by difficulty getting to or maintaining sleep (waking up at night or early in the morning). Sedative antihistamines can be used as a temporary aid to help with sleeping problems.

This post will review all over-the-counter sleeping pills (OTC) available in the UK. All of the non-prescription sleeping pills available in the UK contain sedative antihistamines. 

What Causes Insomnia?

Many factors can cause insomnia. Some common include stress and Anxiety. Changing your sleeping habits should always be considered before trying sleeping pills. Many online resources, including NHS and Mind websites, offer excellent tips on improving your sleep.

Over The Counter Sleeping Pills UK: Active Ingredients

All products available over the counter 'for sleeping' contain sedative antihistamines as the main active ingredient. Two sedative antihistamines used in the formulation of sleeping pills in the UK are diphenhydramine and promethazine.

Both diphenhydramine and promethazine belong to a group of first-generation antihistamines. The main side effects associated with using 1st generation antihistamines are drowsiness and sedation, which is mainly due to the ability of this group of drugs to cross the blood-brain barrier (BBB) and its effect. BBB stops harmful toxins, pathogens, and drugs from reaching the brain.

The second generation of antihistamines, such as loratadine and cetirizine, which can also be purchased over the counter for the treatment of allergies, cross the blood-brain barrier in significantly smaller amounts compared to the first generation of antihistamines.

Dizziness is, therefore, an infrequent side effect of those antihistamines. Generally, the second generation of antihistamines is classified as non-drowsy antihistamines.

Sedative Antihistamines: Common Side Effects

People who take sedative antihistamines may experience side effects.

The table below lists common side effects that may be experienced when taking over-the-counter sleeping pills containing sedative antihistamine. No frequency information is given for promethazine (common / very common / rare).

Diphenhydramine Promethazine
Fatigue Drowsiness, confusion, dizziness, headaches
Sedation, drowsiness, dizziness Dry mouth and throat, stomach upset
Dry mouth and throat  

Tolerance And Addiction

Are over-the-counter sleeping pills addictive?

There is no evidence suggesting that over-the-counter sedative antihistamines such as diphenhydramine and promethazine are addictive. It is reasonably safe to buy diphenhydramine and promethazine.

Tolerance of sleeping products

Over-the-counter sleeping pills containing diphenhydramine and promethazine have some role in the short-term management of sleeping difficulties.

However, it has been documented that when used regularly, tolerance develops rapidly (Vande Griend, Anderson, 2003), Within a few days of starting the treatment.

Simply put, you are less likely to benefit from the treatment, such as help falling asleep when antihistamines are taken regularly.

Over The Counter Sleeping Pills UK: Differences Between Drugs

From the patient's choice perspective, the main difference between both drugs is the duration of action. There is no strictly defined duration of action for each antihistamine; however, it is estimated that:

  • Sleeping products containing diphenhydramine last between 4-8 hours
  • Sleeping products containing promethazine last between 8-12 hours

The above figures are just an estimate. Patients are usually advised that they may feel sleepy and tired in the morning after taking any of the sedative antihistamines.

Who Should Not Have Over-The-Counter Sleeping Tablets?

The following patients should not take sedative antihistamines:

  • Patients outside of the licensed age group (see details for each specific product)
  • Patients who take monoamine oxidase inhibitors (MOI) or recently stopped taking MOI (in the last 14 days)

Additionally, several 'cautions' on the use are related to different conditions, such as asthma, narrow-angle glaucoma, epilepsy, or medication taken, for example, tricyclic antidepressants, like amitriptyline. Please read the product information leaflet or speak to the pharmacist before use for more information.

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Lemborexant has a low potential for Abuse as compared to Suvorexant.
Lemboxerant is a central nervous system depressant drug belonging to the drug class Sedative hypnotics, which helps with sleeping problems.

Where To Buy Over The Counter Sleeping Pills UK?

All diphenhydramine and promethazine products are classified as pharmacy-only medicines (P). P products can only be sold from registered pharmacies, including online chemists. P medicines must be requested from the pharmacy counter as they are unavailable for self-selection by customers.

What Is The Best Over The Counter Sleeping Pill In The UK?

There is no evidence to suggest promethazine is superior to diphenhydramine and vice versa. Both drugs get quickly into the body and cause sedation and drowsiness. Promethazine stays in the body for longer, giving possibly longer sedation time.

With this in mind, Phenergan Night-Time and Phenergan 25mg (each tablet contains 25mg of promethazine) may be the best over-the-counter sleeping pills in the UK.

The Best Over The Counter Sleeping Pills UK Options

Diphenhydramine is the best sleeping pill in the UK.

1. Nytol Original and Nytol One a Night

Nytol is probably the most known brand of over-the-counter sleeping aids. Nytol contains diphenhydramine hydrochloride as an active ingredient.

Nytol Original and One a Night are available only from pharmacies.

Nytol is available in two forms:

  • Nytol Original: each tablet contains 25mg of diphenhydramine hydrochloride.
  • Nytol One a Night: each tablet contains 50mg of diphenhydramine hydrochloride.

Nytol: restrictions on age and duration of the use

Children and adults can use Nytol Original and Nytol One Night over 16 years. Nytol should not be used for more than two weeks without getting advice from a doctor.

Can you use Nytol in pregnancy or when breastfeeding?

Nytol is not recommended during pregnancy. Diphenhydramine is excreted in breast milk; however, the effect on infants is unknown. Customers who breastfeed and want to use Nytol need to speak to their GP before using Nytol.

2. Nytol One a Night alternative products

Customers can purchase several equivalent products from different pharmacies which contain 50mg of diphenhydramine. The products listed below are made by the same Company (Omega Pharma Ltd), One A Night. Essentially, it is the same drug, packed and marketed for different pharmacies and sold at a considerably lower price:

  • Galpharm One a Night Sleep Aid 50mg Tablets
  • Numark Sleep Aid 50mg Tablets
  • Superdrug One-A-Night Sleep Aid 50mg Tablets
  • Sleepeaze 50mg Tablets
  • Morrisons One-a-Night Sleep Aid 50mg Tablets
  • Tesco Health Sleep Aid 50mg Tablets

The same restriction on the use applies to all products listed above.

3. Nytol Original alternative products

It may be no surprise that the same producer also makes some Nytol Original alternative products. The exact age restrictions and limits on the use apply to all products listed below.

  • Numark Sleep Aid 25mg Tablets
  • Superdrug Sleep Aid 25mg Tablets
  • Sleepeaze 25mg Tablets
  • Asda Night Time Sleep Aid 25mg Tablets
  • Morrisons Sleep Aid 25mg Tablets
  • Tesco Sleep Aid 25mg Tablets

4. Over-the-counter sleeping aids: Nytol liquid

Although we are reviewing the availability of over-the-counter sleeping pills, we wanted to mention that Nytol, which contains diphenhydramine, is also available as a temporary aid for sleeping problems in the form of liquid. The Nytol liquid review summarises the product indications, age limits, and potential adverse effects. The link above also discusses the distinctions and similarities between Nytol liquid and Nytol pills.

5. Panadol Night (Panadol NightPain)

Panadol Night contains two active ingredients: paracetamol and diphenhydramine. It is a pharmacy-only medication licensed for short-term treatment of pain experienced at bedtime. A wide range of conditions that cause difficulty in getting to sleep can be managed with Panadol Night, for example:

  • Toothache
  • Backache
  • Muscle pain
  • Headache
  • Period pains

There is nothing unusual about this product. Each tablet contains 500mg of paracetamol and 25mg of diphenhydramine (equivalent amount of diphenhydramine to Nytol Original). A maximum of two tablets can be taken at night.

Who can use Panadol Night?

Children and adults can use panadol Night over 16 years of age for the maximum duration of 7 days.

6. Cold and flu products containing diphenhydramine

Several cold and flu cough products contain diphenhydramine to manage cold and flu symptoms to help sleep. These come in the form of tablets or liquids. A familiar brand of cold and flu tablets containing diphenhydramine:

  • Benylin Day & Night Tablets: paracetamol with pseudoephedrine hydrochloride (day tablets) or diphenhydramine hydrochloride (night tablets.
  • Benylin Four Flu tablets: the same combination of drugs as the above product.

Promethazine Containing: The Best Over The Counter Sleeping Pills UK

Two brands of promethazine for sleep aid products available in the UK are:

  • Sominex
  • Phenergan Night-Time
  • Phenergan (10mg and 25mg)

1. Sominex sleeping tablets

Sominex is a pharmacy-only medication used temporarily as a sleeping aid. Each Sominex tablet contains 20mg of Promethazine hydrochloride.

Who should not use Sominex?

Patient groups who should not use Sominex (promethazine) include:

  • Patients taking an antidepressant Monoamine oxidase inhibitor (MAOIs) or who recently stopped the treatment with MOI (in the last 14 days)
  • Patients with Central Nervous System (CNS) Depression
  • A patient is allergic to promethazine and any ingredients found in the formulation of Sominex tablets.

Sominex: restrictions on age and duration of the treatment

Sominex is licensed for children and adults who are 16 years or older.

The maximum recommended duration of the treatment is seven days. Patients should seek medical advice if more prolonged use is required.

Can you use Sominex in pregnancy or when breastfeeding?

Pregnant or breastfeeding women should speak to their doctor before using Sominex.

2. Phenergan Night-Time sleeping tablets

Phenergan Night Time is another pharmacy-only medication used as a sleeping drug. Phenergan Night Time contains 25mg of promethazine per pill (slightly more than Sominex).

Children and adults can use Phenergan Night Time over 16 years of age.

Children and adults can use Phenergan Night Time over 16 years of age. The same restrictions on the use apply to Phenergan Night-Time as with previously reviewed Sominex. Like Sominex, patients who want to use Phenergan Night time for more than seven days should contact their GP to discuss the treatment.

Can you use Phenergan Night Time during pregnancy or when breastfeeding?

Don't hesitate to get in touch with your GP for more advice. Generally, Phenergan should not be used in pregnancy unless a GP decides the treatment is essential.

3. Phenergan 10mg and Phenergan 25mg

Promethazine is also available as Phenergan 10mg and 25mg tablets. The main active ingredient in both products is promethazine, 10mg per tablet and 25mg per tablet.

Both products are pharmacy-only medicines.

Not all pharmacies may display Phenergan 10mg or 25m on display. You may need to ask a pharmacy team member to get it from the dispensary should you wish to purchase this product.

Phenergan vs Phenergan Night-Time

The first question that can come to your mind is: What is the difference between Phenergan Night and Phenergan? since both products contain the same active ingredient.

Differences in both products related to:

  • Licensed use (what conditions can be treated)
  • Age restrictions on the use
  • Restrictions on the use duration
  • Number of tablets per box
  • Price

The table below highlights the differences between Phenergan Night-Time and Phenergan tablets.

Drug Brand

Phenergan Night-Time

Phenergan tablets

Active ingredient



Amount of active ingredient per tablet


25mg or 10mg

Licensed treatment

Insomnia only

Allergic conditions, antiemetic (to stop nausea), insomnia in children and adults

Age restrictions on the use

16 years and above

For insomnia: from 5 years of age

Maximum treatment duration

7 days. Seek medical advice after

7 days. Seek medical advice after

Number of tablets per box

14 tablets

56 tablets




Price per tablet



* Phenergan Elixir is licensed for children aged 2-5 years.

** Recommended retail price (RRP) taken from C&D (09/2020)

4. Phenergan alternative products

Generic promethazine 10mg tablets

Promethazine 10mg tablets are available as pharmacy-only medication in a 'generic' form (Genesis Pharmaceuticals). Genesis promethazine has the same licensed use (allergies, anti-sickness, and sleeping aid) age restrictions.

And the maximum recommended duration of use is Phenergan tablets.

5. Cold and flu products containing promethazine

Promethazine is one of the main active ingredients in a combination of products used to relieve 'cold and flu symptoms. 'Cold and flu' products containing promethazine come in capsules and liquid.

The most popular brand of promethazine-containing product is Day & Night Nurse Capsules, available as a combination pack (Day Night capsules), Night Nurse Capsules, or Nigh Nurse liquid.

When used as a 'cold and flu product, the 'night' capsule contains a combination of promethazine, dextromethorphan (to stop the cough), and paracetamol (to reduce temperature and help with fever symptoms and aches).

Night Nurse equivalent brands, which contain the same active ingredient, include:

  • Fedril Night Cold and Flu, Oral Solution
  • Lloyds Pharmacy Night Cold and Flu Relief, Oral Solution
  • Numark Night Cold and Flu, Oral Solution
  • Boots Night Cold & Flu Relief Oral Solution

Over The Counter Chlorphenamine (Piriton) For Sleeping

Can you use chlorpheniramine (brand name: Piriton) as a sleeping aid product? 

Similarly to promethazine and diphenhydramine, chlorphenamine is classified as 1st generation antihistamine.

As we established earlier, 1st generation antihistamine causes drowsiness and sedation.

Sedation is listed as a widespread side effect of chlorphenamine tablets.

In the UK, chlorphenamine is a pharmacy-only medication that can be purchased for the symptomatic management of allergic conditions, such as hay fever, insect bites, or food allergies.

Although chlorphenamine may be of some use to help with insomnia, this use is outside of the product license.

Can You Get Melatonin Over The Counter In The UK?

Melatonin is the most popular sleeping aid product in the USA, available without a prescription. Melatonin is a hormone which is secreted at night in the brain. Melatonin causes fewer side effects (compared to sedative antihistamines) and has improved insomnia (Costello et al., 2014).

In the UK, Melatonin is a prescription-only medication (POM). The most common brand in the UK is Circadin, which comes in prolonged-release tablets (2mg of Melatonin per tablet). The newest POM Melatonin to enter the UK market is Slenyto, which also comes in prolonged-release tablets (1mg and 5mg of Melatonin per tablet).

Circadin is licensed for short term-management of insomnia in adults over 55 years of age. So far, it has been prescribed (unlicensed use) to treat insomnia in children.

Newly launched Slenyto tablets are licensed to treat insomnia in children and adolescents aged 2-18 with Autism Spectrum Disorder (ASD) and Smith-Magenis syndrome. 

Are Sleeping Pills For Me?

Sleeping aids may be suitable for some as a temporary solution to their sleeping problem. Long-term Safety of sleeping products has not been evaluated, hence the restrictions on their use. Few important points to consider before using over-the-counter sleeping pills:

  • What causes your sleeping problems?
  • Have you tried changing your sleeping habits?
  • Do you have insomnia often?
  • Are you taking any other medication?
  • Do you have any other underlying conditions?
  • Are you aware of other side effects caused by sleeping pills?
  • Are you using sleeping pills regularly?

Always read the product information leaflet before using any over-the-counter medication, and speak to your doctor if you have insomnia regularly.

Over The Counter Sleeping Pills: Herbal Products

Customers have an excellent choice of herbal products, which can help with sleeping problems. Herbal remedies are based on traditional use. The most common herb used is valerian. The effectiveness and availability of herbal products in managing insomnia will be subject to an independent review.

Ingredients Of Herbal Sleeping Pills Contained

You will be safe after consuming the medicine due to its non-addictive properties that will not keep you dizzy the next day. You can take one capsule daily and see the improvements in a few nights of consumption.

Valerian root

It is one of the natural ingredients used in herbal products. It is a plant that grows in Europe and has been used for more than thousands of years to work on sleep. Valerian root works directly on the brain and central nervous system. Studies have shown that if someone consumes 450mg of herbal product that includes Valerian root, they tend to sleep peacefully.

Lavender and Chamomile

These ingredients are primarily used in teas that give a calming effect on the brain and help get a soothing sleep. It is one of the most commonly used herbs in the world.

5-Hydroxytryptophan (5-HTP)

5-Hydroxytryptophan is a protein that is extracted from the Griffonia seed. 5-HTP acts on the serotonin level and works on Anxiety, depression and insomnia.


Magnesium is a nutrient that helps the body to be relaxed. It acts on your muscles and nervous system for sleep.

1- Kalms Night One-A-Night Sleeping Tablets

Most people do not like to go for something that can be harsh on them, so they tend to prefer opting for herbal products. Here is an alternative to sedative tablets, and kalms are an attractive option for treating their sleep. It contains ingredients such as valerian root. Compared to other medicines, Kalms take days to get into the body to sleep fully. You should consult the doctor after 4 weeks if you don't feel any changes in your sleep disorder. Mostly, valerian root is not an addictive substance. It also doesn't show any side effects compared to other medicines.

2- Nutrienne 5HTP+ Sleep Capsules

Nutrienne is a prescription-based drug. Most US people opt for curing their insomniac problems and getting rid of the situations they face. It comprises herbal products that include 5-HTP, magnesium, Griffonia seeds, lavender and chamomile.

3- Microbz Bio-Live Sleep

Microbe Bio-Live Sleep is a liquid medicine that stays in your stomach and gives you a relaxing feel. It is considered a probiotic as well as sleeping medicine. It contains herbal ingredients such as Valerian root and chamomile. It will help you in getting better sleep in the long term.

How To Find The Right Sleeping Medication?

There are situations where you get different alternatives and various forms of combination medicine to treat your problem, but the question arises what would be the best choice for me? 

In terms of sleeping pills, every medication works perfectly fine; no matter what, you would get the desired sleep after consuming the medicine. When it comes to choosing, it's the trial and test process. This would be recommended by the doctor after the diagnosis and knowing the exact reason for the problem. 

If at all the first prescribed drugs from the doctor didn't work, then you can ask, or the doctor will recommend an alternative medicine that would be helpful for you in getting a peaceful sleep. 

What Are The Ingredients Presented In Sleeping Pills?

Almost all sleeping belongs to the drug class of Sedative hypnotics. This works best for creating a dizzy effect on your brain. But the question arises what type of ingredients are presented in the pills that a person doses quickly?

So here. Melatonin comes in place. Melatonin is a hormone that will boost the sleeping effect on your body. You Can Get Melatonin over the counter in the UK, but it is classified as a prescription-only medication. Hormones that are connected to the brain differ as per the lights outside. These hormones play a role in the morning. During the dark, the hormones increase, whereas if you are in bright sunlight, hormones decrease. This hormone will prepare your body for sleep if you use any sleeping medicine. 

Final Words From Druggist

All the medications presented above have their effects on the body. Medications are differentiated to understand better and help you know their uses and how they will work on the body for sleep disorders or problems. Not being entirely dependent on sleeping medicines for your better cause is always recommended. Be wise to choose the topic, and before getting any medicine to treat the problem, get a piece of proper knowledge about the usage from your medical practitioner.

  • Costello RB, Lentino CV, Boyd CC, et al. The effectiveness of Melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutr J. 2014;13:106. Published 2014 Nov 7. doi:10.1186/1475-2891-13-106 Available at: Accessed on 05/09/2020
  • Daneman R, Prat A. The blood-brain barrier. Cold Spring Harb Perspect Biol. 2015;7(1):a020412. Published 2015 Jan 5. doi:10.1101/Csh Perspect.a020412 Available at: Accessed on 03/09/202
  • Vande Griend, Anderson (2003). Histamine-1 receptor antagonism for treatment of insomnia. Available at: Accessed on 30/03/2019


Why lose hope, when you can lose weight.

Loose plenty of weight with plenity.