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Best Pain Reliever For Toothache


In a pharmacy, patients request a pain relief medication due to a toothache quite commonly. Seeing a dentist investigate the cause of pain is crucial. In the meantime, the patient may consider the use of over-the-counter medicines to manage the pain. Although it is difficult to point out a single best pain reliever for toothache, patients may see pain reduction with any of the drugs reviewed below.

A combination of two or even three different products is possible with over-the-counter medicines. I will discuss leading painkillers available in pharmacies for the management of a toothache. I will also list a few prescription-only drugs which can be prescribed by a dentist.

Management Of Dental Pain With Paracetamol

Paracetamol is a ‘gold standard in the management of pain and is usually recommended as the first option for mild pain. Customers can purchase Paracetamol over the counter in all supermarkets, pharmacies, and ‘corner’ shops. When severe pain is experienced, patients need to maximize the use of Paracetamol by taking the full recommended dose. The recommended dose for Paracetamol in adults and children over 16 years of age is 1 to 2 tablets, taken every 4-6 hours, as required. Don’t take more than eight tablets (4 doses) in any 24 hours.

Paracetamol helps to reduce pain and fever (high temperature) if present. High temperature with a toothache is possible when a dental abscess (infection) is present. Paracetamol can be taken with other pain relief drugs for a toothache, such as Nonsteroidal Anti-inflammatory Drug (NSAIDs), which are discussed in the next paragraph.

Quick FAQ

Which Paracetamol is best for toothache?
We recommend the brand Panadol, which is effective paracetamol for dental pain. Paracetamol is generally safe for most people.
How long does it take for Paracetamol to work for a toothache?
It takes up to an hour for Paracetamol to work. The effect typically lasts for 5 hours.
Can Paracetamol make toothache worse?
Paracetamol typically does not make toothache worse, in fact, it is an effective painkiller. However, it is less effective in reducing swelling, and we suggest you take it with ibuprofen if you have swelling.

Is Paracetamol The Best Pain Reliever For A Toothache?

Paracetamol is considered an effective painkiller for toothache. When taken in combination with NSAIDs such as Ibuprofen, Paracetamol has shown to be more effective in pain reduction than combination products containing Codeine (Teoh, 2020).

Best Pain Reliever For Toothache: Nonsteroidal Anti-inflammatory Drug (NSAIDs)

Ibuprofen is the most common NSAIDs available over the counter. Customers can purchase Ibuprofen 200mg in shops and pharmacies, where a product is available for self-selection and limited in sale to two packs of 16 tablets. It is possible to buy ibuprofen 400mg tablets from a pharmacy counter and up to 100 tablets. Read more about over-the-counter Ibuprofen.

Ibuprofen has two actions in the body. It reduces fever and inflammation. As an anti-inflammatory drug, Ibuprofen is less effective than other (prescription) NSAIDs; however, it is associated with a lower possibility of side effects. Similar to Paracetamol, Ibuprofen can be taken at a maximum dose to get the best pain relief effect. The maximum recommended daily dose for Ibuprofen 400mg is one tablet to be taken up to three times a day (when required).

Ibuprofen can be used together with Paracetamol at the same time (adults). In fact, one branded combination product which contains Paracetamol and Ibuprofen is available in the UK. Nuromol tablets contain a combination of Paracetamol with Ibuprofen in one pill. Information provided by the manufacturer of Nuromol suggests that this drug is more effective as a painkiller as compared to taking individual drugs alone.

Nuromol is a pharmacy-only product, which means customers can only buy it from pharmacies, including online chemists. Branded versions of Ibuprofen 200mg and 400mg are available in the form of liquid capsules (Nurofen Express), which may provide for faster pain relief as compared to a standard formulation of Ibuprofen tablets.

NSAIDs Effectiveness In Acute Toothache

NSAIDs are regarded as the first option when it comes to the management of dental pain. Some evidence exists, which suggests NSAIDs are better (more effective) for a toothache than opioids such as Codeine (Teoh, 2020) owing that not only NSAIDs reduce pain but also swelling and hyperalgesia (sensitivity to the pain). NSAIDs, together with Paracetamol, are regarded as the first-line option in the management of toothaches.

Use Of Aspirin As A Pain Reliever For A Toothache


Aspirin also belongs to the NSAIDs group of drugs.

Aspirin is used in the management of pain, including toothaches. When used as a painkiller, the standard formulation of Aspirin contains 300mg of aspirin as an active ingredient.

Higher dose Aspirin differs from a low-dose Aspirin (baby Aspirin), which some people take daily as secondary prevention of cardiovascular diseases, such as deep-vein thrombosis (formation of a blood clot in the vein) or pulmonary embolism (formation of a blood clot in blood vessels found in the lungs). Aspirin is available as a combination product, for example, Anadin Extra tablets (aspirin, caffeine, Paracetamol).

Quick FAQ

What’s better for toothache, Ibuprofen, or Aspirin?

Aspirin is effective for toothache and also an NSAID belonging to the same category as Ibuprofen. However, Ibuprofen is often particularly effective for dental pain than Aspirin.

How long does it take for Aspirin to work?
Aspirin starts to work within 16 minutes and brings effective pain relief after 49 minutes, according to Bayer.
Can you place Aspirin on your tooth?
No, you should not place and hold aspirin directly on your tooth for long as it may cause more trouble. The name of aspirin is acetylsalicylic acid, and the acid can burn your gums if held for too long.
Can I crush Aspirin for a toothache?
Yes, you can crush Flavored Baby Aspirin to apply it directly on the decayed area of the tooth. When dissolved on its own, it can give relief from the pain.

Codeine Combination Products As Pain Relief For A Toothache


Combination products containing Codeine are usually recommended (licensed)

when customers try first-line painkillers such as Paracetamol or Ibuprofen and don't get sufficient pain relief.

A variety of combination products containing Codeine can be purchased from a pharmacy to manage toothache.

Combination products containing Codeine are available in different forms (tablets, capsules, and effervescence tablets). The amount of Codeine per pill differs between brands of Codeine-containing products. The drugs listed below are everyday Codeine-containing products available in most pharmacies. Some may regard codeine-containing medicines as the best pain relievers for toothache; however, the evidence suggests otherwise.

Is Codeine The Best Pain Reliever For A Toothache?

Management of dental pain with Codeine has limited use. Many customers request over-the-counter co-codamol to help with a toothache. Perhaps one benefit of Codeine is that it can cause drowsiness and sedation, which may be favorable when a toothache is experienced at night.

Several studies have demonstrated that taking Paracetamol with Codeine does not improve pain control as compared, for example, to taking Ibuprofen and Paracetamol in combination. In one study of 131 dental patients (surgical removal of a molar) addition of Codeine 60mg to a combination of Paracetamol and Ibuprofen did not reduce the pain more effectively as compared to treatment with just Ibuprofen and Paracetamol (Best et al., 2017). A review of 23 clinical trials involving patients with post-operative pain concluded that taking Ibuprofen is more effective than taking Paracetamol or Paracetamol and Codeine (BMJ, 2000).

Codeine Products For Toothache: Limit On The Use

Products that contain codeine should not be used for more than three days when purchased over the counter. Limit on the use of Codeine products reflects the addictive properties of Codeine.

Possible Side Effects With Codeine Products

Taking Codeine and Codeine-containing product is associated with side effects. The most common side effect which may be experienced are:

  • Nausea (feeling sick)
  • Drowsiness/sedation (feeling sleepy)
  • Constipation

Lastly, there is a variation in response to Codeine between people who take this drug. In simple terms, some people may experience a little effect from Codeine; others may be affected much more and experience a number of side effects, even with products taken over the counter.

Codeine And Paracetamol (Co-codamol) For A Toothache

Is co-codamol the best pain reliever for toothache?

Co-codamol is one of the most commonly requested over-the-counter painkillers.

Co-codamol can be considered as an analgesic option to relieve acute moderate pain, including toothache, which is not managed successfully by other analgesics such as Paracetamol or Ibuprofen (alone).

‘Standard’ Co-codamol tablet contains 500mg of Paracetamol and 8mg of Codeine. Co-codamol is available as tablets or effervescent tablets, which dissolve in the water. Most pharmacies sell Co-codamol as their own branded product, which is usually the cheapest option. Plenty of other brands exist, for example, Vegan, which does not differ a lot in terms of active ingredients.

Some brands of Codeine products contain more than 8mg of Codeine per tablet, for example, Solpadine Max range of Co-codamol:

Solpadeine Max Tablets (Codeine, Paracetamol)

Solpadeine Max Tablets

  • 12.8mg of Codeine and 500mg of Paracetamol per tablet
  • Available in 'standard' tablet formulation and as effervescent tablets
  • Suitable for children and adults from 12 years of age
  • An adult can take two tablets up to 4 times a day

Solpadine Plus (Caffeine, Codeine, Paracetamol)

  • 8mg of Codeine and 500mg of Paracetamol, and 30mg of caffeine per capsule
  • Available in the capsule forms or as effervescent tablets
  • Suitable for children and adults from 12 years of age
  • An adult can take two tablets up to 4 times a day

You can read more about over-the-counter co-codamol in one of my previous posts.

Codeine And Ibuprofen For A Toothache

Codeine can also be bought in combination with Ibuprofen. Nurofen Plus contains 200mg of Ibuprofen and 12.8mg of Codeine per tablet. Nurofen Plus can be used by adults and children over 12 years of age. Similar to Co-codamol, Nurofen Plus is licensed for the management of acute pain such as toothache, which is not relieved by simple analgesics such as Paracetamol, Ibuprofen, or Aspirin alone. Nurofen Plus (Codeine and Ibuprofen) can be taken alongside Paracetamol. The use of Nurofen Plus is limited to three days only.

Dihydrocodeine and Paracetamol – Co-dydramol (Paramol) As A Pain Reliever For A Toothache


Paramol tablets are made up of a combination of two active ingredients: Paracetamol 500mg and Dihydrocodeine 7.46mg per tablet, commonly known as Co-dydramol.

Similar to Co-codamol, Co-dydramol is a weak Opioid.

It has similar pain relief properties to that of Codeine.

With higher doses (prescription-only), Dihydrocodeine may offer additional pain relief, however, at the expense of nausea and vomiting (BNF, 2020).


Effectiveness Of Co-Dydramol As A Pain Reliever In Toothache

Customers who consider taking over-the-counter Co-dydramol may not experience a significant benefit in relieving toothache as compared to a combination of other simple analgesics. No specific studies comparing the effectiveness of Co-dydramol with other analgesics exist. One study which looked at the efficacy of Dihydrocodeine as compared to Ibuprofen as a single dose in post-operative patients concluded that Ibuprofen (400mg) is a better pain reliever than either Dihydrocodeine 30mg or 60mg (Cochrane, 2000).

Local Anesthetic Gels As A Pain Reliever For A Toothache

Local anesthetic gel offers an additional treatment option for people who experience toothache pain. Local anesthetic gels are used as temporary relief from a toothache. Oral gels are applied locally into the tooth cavity. In the UK, Orajel is the local anesthetic gel that is used as a pain reliever for toothache.

Orajel is sold As Two Different Products:

  • Orajel Dental Gel (local anesthetic: 10% benzocaine) is available as a general sale product, for self-selection by customers, for example, in supermarkets, pharmacies, and online.
  • Orajel Extra Strength (local anesthetic: 20% benzocaine) available as a pharmacy-only product

Orajel Dental and Orajel Extra Strength can be used by adults and children over 12 years of age. Orajel can be used alongside other analgesics such as Paracetamol and Ibuprofen.

Is Orajel Useful As A Pain Reliever For A Toothache?

A study of 576 participants with acute toothaches found that benzocaine 10% and 20% is more effective than placebo (a dummy product) when applied locally to an open tooth cavity and surrounding oral tissues. Benzocaine 20% was more effective in relieving pain than 10% gel. Overall, the study concluded that Orajel is effective, well-tolerated, and patients can use it safely as a temporary treatment of toothache. (Hersh et al., 2013).

Prescription-Only Medicines For A Toothache

NHS Dentist (Appointment)

A dentist may prescribe a drug(s) to help to manage toothache pain. Only limited drugs can be prescribed by a dentist when an NHS dental prescription is issued. In terms of pain management, only the following medicines can be prescribed on NHS dental prescription:

  • Aspirin
  • Diclofenac Sodium Tablets
  • Dihydrocodeine Tablets (30mg)
  • Paracetamol tablets and oral solution

As we can tell, the above options are limited in terms of pain management, although Diclofenac (another NSAID) is a more effective pain reliever as compared to Ibuprofen. Dihydrocodeine 30mg is a prescription-only medication. Some patients may find that a higher dose of Dihydrocodeine is more effective in reducing pain than over-the-counter products containing Codeine or Dihydrocodeine. However, this may happen at the expense of side effects.

Private Dentist (Private Visit)

A dentist can prescribe almost any medicine when a private prescription is issued. Prescribing drugs on a private prescription broadens the choice of painkillers. Dentists cannot legally write a private prescription for ‘stronger’ painkillers, for example, schedule 3 controlled drugs (e.g., Tramadol) or schedule 2 controlled drugs, such as morphine-based drugs, e.g., morphine sulfate tablets.

Alternative options for drugs that may be prescribed by a dentist on private prescription include:

  • Naproxen: First choice when it comes to prescribing NSAID (same class of drugs as Ibuprofen or Diclofenac). Naproxen is more effective than Ibuprofen, with similar effectiveness to Diclofenac but with a low occurrence of side effects.
  • Co-codamol: Higher strength of Co-codamol tablets or capsules such as Co-codamol 30/500 (30mg of Codeine and 500mg of Paracetamol)
  • Ibuprofen: Higher strengths of Ibuprofen (above 400mg) exist, for example, Ibuprofen 600mg tablets or Ibuprofen 800mg modified-release tablets. When prescribed, Ibuprofen can be taken at a higher dose than that of Ibuprofen purchased over the counter. A dentist or a doctor can prescribe Ibuprofen with the highest dose of up to 600mg of Ibuprofen taken four times a day. A maximum daily dose of Ibuprofen – 2400mg. The maximum daily amount for over-the-counter Ibuprofen is 1200mg.
  • Meptazinol (brand name Meptid): Another option for prescription-only opioids, which is used in the short-term management of moderate pain.

Best Pain Reliever For Toothache: Conclusion

Teeth relief

Paracetamol and Ibuprofen (NSAID) should be considered as first-choice medicines in the management of toothache.

Adults cant take Paracetamol and Ibuprofen at the same time. This advice is different for children.

Over the counter, Codeine or Dihydrocodeine containing a product may offer less pain relief when experiencing a toothache. Instead, patients may experience side effects associated with opioid use, such as drowsiness, sedation, nausea, and constipation.

In addition to oral drugs for pain management, customers have a choice of a local anesthetic gel like Orajel, which is proven to relieve dental pain. Orajel or Orajel Extra can be used alongside standard analgesics such as Paracetamol or Ibuprofen.

Customers who experience severe toothache should consider the use of two analgesics with the possible addition of a local anesthetic gel. Additionally, one needs to optimize pain management by taking the full recommended dose of the drug as per product instructions.

Lastly, customers need to remember that many over-the-counter products contain similar ingredients, and not all products can be taken at the same time. Always read the product information leaflet before taking medication and follow manufacturer directions or directions from your prescriber. If in doubt, speak to your pharmacist.

What is your best pain reliever for a toothache? Please leave a comment below.

Quick FAQ

Which is best painkiller for toothache?
There is no single best painkiller for a toothache. Patients should consider the use of a combination of medicines, such as paracetamol and ibuprofen in addition to a local anesthetic gel to make the best treatment option.
What is the best OTC pain reliever for toothache?
Patients who seek the best OTC pain relief medication should consider using a combination of 2 or 3 single medicines as described in the above post.
  • Best AD, De Silva RK, Thomson WM, Tong DC, Cameron CM, De Silva HL. Efficacy of Codeine When Added to Paracetamol (Acetaminophen) and Ibuprofen for Relief of Postoperative Pain After Surgical Removal of Impacted Third Molars: A Double-Blinded Randomised Control Trial. J Oral Maxillofac Surg. 2017 Oct;75(10):2063-2069. doi: 10.1016/j.joms.2017.04.045. Epub 2017 May 15. PMID: 28586638. Available at: https://doi.org/10.1016/j.joms.2017.04.045 Accessed on 28/10/2000
  • Hart, F.D. and Huskisson, E.C., 1984. Non-steroidal anti-inflammatory drugs. Drugs27(3), pp.232-255.BMJ (2000). Non-steroidal anti-inflammatory drugs. Available at: https://link.springer.com/article/10.2165/00003495-198427030-00004 Accessed on 28/10/2000
  • Twycross, R.G., 1984. Analgesics. Postgraduate medical journal60(710), p.876. BNF (2020). Analgesics. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418085/  Accessed on 29/10/2020
  • Hersh EV, Ciancio SG, Kuperstein AS, et al. An evaluation of 10% and 20% benzocaine gels in patients with acute toothaches: efficacy, tolerability and compliance with label dose administration directions. J Am Dent Assoc. 2013;144(5):517-526. doi:10.14219/jada.archive.2013.0154 Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844156/ Accessed on 29/20/2020
  • Teoh L. Managing acute dental pain without codeine. Aust Prescr. 2020;43(2):64. doi:10.18773/austprescr.2020.013 Available at: https://dx.doi.org/10.18773%2Faustprescr.2020.013 Accessed on 28/10/2020
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