Druggist Menu
Post Highlights

Cialis Vs Viagra: Which ED Medication Is Better?

Cialis vs Viagra

Erectile Dysfunction (ED) medications are commonly known as either Viagra (sildenafil) or Cialis (tadalafil), which are very widely prescribed medications in the United States for approximately 30 million men who are suffering from ED.

The invention of Viagra was a significant event in this history for men’s sexual health. It was the first oral medication for erectile dysfunction (ED) approved by the FDA in 1998. There were about 5.3 million prescriptions written for Viagra in its first six months of approval in 1998. There were about 5.3 million prescriptions written for Viagra in its first six months of approval. Less than 4% of men sought ED treatment before Viagra was approved. The percentile rose to 20% within the following two years.

Cialis and Viagra are oral drugs primarily used to treat ED belonging to the phosphodiesterase-5 (PDE5) inhibitor class of drugs. Cialis was first approved by the FDA much later on, on the 21st November 2003, manufactured by Eli Lilly and Co, whereas the FDA approved Viagra on 27th March 1998, manufactured by Pfizer. Reputable and multinational pharmaceutical companies developed both.

How Cialis and Viagra Work

The primary function increases blood flow to a male’s genital organ, causing penile erection. During sexual arousal, this causes the creation and release of nitric oxide in the penis under normal circumstances. The enzyme guanylate cyclase is activated, resulting in cyclic guanosine monophosphate (cGMP). The cGMP is principally responsible for the erection by influencing the volume of blood delivered and removed from the penis by the blood vessels. Both Cialis and Viagra work by inhibiting the enzyme phosphodiesterase-5 (PDE5), which breaks down the cGMP. Cialis and Viagra prevent cGMP from being destroyed, accumulating, and persisting longer in the bloodstream. The longer cGMP stays in the body, the longer the penis engorges.

Age Restriction

It has been proven safe in men as young as 85 years old. Children under the age of 18 have not been tested with Viagra. Please be advised that youths more youthful than 18 years old should not use these medications.

Condition Treated

Cialis:

Cialis is primarily used to treat erectile dysfunction (ED). However, it is also licensed to treat the signs and symptoms of an enlarged prostate, also known as benign prostatic hyperplasia (BPH). Adcirca is a drug that contains tadalafil, similarly to the active ingredient of Cialis, but is intended to treat pulmonary arterial hypertension or high blood pressure in the lungs.

Viagra:

The FDA approved Viagra for only treating ED. The active ingredient in Viagra, sildenafil citrate, is also sold as Revatio to treat pulmonary arterial hypertension (PAH). Raynaud’s phenomenon and female sexual arousal disorder are two conditions for which Viagra is sometimes prescribed off-label use only when necessary or after consultation with their healthcare physicians.

Cialis and Viagra have been given to treat the various issues associated with ED. Viagra, for example, may aid men who have trouble controlling their ejaculation. Cialis has been demonstrated to help men with different sexual dysfunctions such as ejaculatory and orgasmic dysfunction.

Cialis and Viagra Dosage

Cialis comes in oral tablets, suggested starting with 10 mg per day for most people. It is administered before sexual activity. The dose may be increased to 20 mg or decreased to 5 mg per day depending on the effectiveness of the response or adverse effects. The Cialis effect might last up to 36 hours. Individuals taking drugs that raise tadalafil levels in the blood should not take more than 10 mg in 72 hours. The suggested amount for once-daily administration without consideration for sexual activity is 2.5 to 5 mg. It is advised to take Cialis once per day according to the prescription by your healthcare physician.

The recommended dose of benign prostatic hyperplasia and ED is 5mg taken daily at about the same time. The dose may be adjusted in the case of patients with reduced kidney or liver function.

Viagra is suggested to take 1 hour before sexual activity, a dose of 25 to 100 mg. Elderly above 65 should start with 25mg before sexual activity. Because Viagra is absorbed quickly, maximum measured plasma concentrations are obtained within 30 to 120 minutes following oral dosage during fasting conditions. When Viagra is taken with a high-fat meal, the absorption rate is slowed, and the time to peak concentration is delayed by an average of 1 hour.

How To Take Cialis And Viagra

Cialis usually takes 16 to 45 minutes to start working, and its effectiveness is unaffected by eating.

Viagra usually takes 30 minutes to act, and its effectiveness may be harmed if taken soon after a high-fat meal. As a result, taking Viagra on an empty stomach is preferable.

Cialis and Viagra Side Effects

Because the medications affect the body in many ways, Viagra and Cialis have similar side effects. The most common side effects of both the drugs are;

  • Headaches
  • Nasal congestion/stuffy nose
  • Back pain
  • Chest pain
  • Facial flushing
  • Heartburn
  • Upset stomach/indigestion
  • Chest pain
  • Temporary blurred vision
  • Dizziness
  • Muscle aches
  • Sore Throat

Cialis and Viagra can cause a rare side effect called priapism, an erection that lasts for four hours or longer.

Cialis’s side effects may last longer than Viagra because it lingers in your body for longer. Viagra’s shorter duration of action may be a better option if you’re prone to adverse effects.

Drugs Interaction With Cialis and Viagra

Antibiotics And Antifungal 

Erythromycin, ketoconazole, itraconazole, indinavir, and ritonavir may reduce the breakdown and clearance of tadalafil from the body. As a result, these medications may raise tadalafil levels in the blood. To avoid adverse effects from high levels of tadalafil, if these medications are taken simultaneously as tadalafil, the dose of tadalafil should be lowered to 10 mg every 72 hours if used as needed or 2.5 mg if taken daily.

Antimycobacterials

Rifampin, carbamazepine, phenytoin, and phenobarbital may lower tadalafil blood levels, potentially lowering tadalafil’s effects.

Tadalafil increases the heart rate and lowers blood pressure caused by nitrates such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and nitroglycerin, which are primarily used to alleviate heart pain. Tadalafil may cause heart discomfort or a heart attack in people taking nitrates for angina by increasing heart rate and dropping blood pressure. As a result, tadalafil should not be used in conjunction with nitrates.

Tadalafil also enhances the blood pressure-lowering benefits of several alpha-blocking medications, such as terazosin, which are typically used to treat excessive blood pressure or prostate enlargement. Before starting tadalafil, people who take these alpha-blockers should be on a steady alpha-blocker dose. Tadalafil should be begun at the lowest dose possible in these cases. If the patient uses tadalafil, the alpha-blocker should be started at the lowest dose possible. It is not suggested to take tadalafil with alpha-blockers to treat BPH.

Interaction With Alcohol

Blood pressure is lowered by both tadalafil and alcohol. As a result, mixing tadalafil with alcohol may result in dangerously low blood pressure, dizziness, headaches, and an elevated heart rate.

PDE5 drugs may impair platelet function, causing bleeding to be prolonged. In individuals with bleeding disorders or active ulcers, tadalafil should be administered with caution. Adcirca (another form of tadalafil) and other PDE5 inhibitors, such as vardenafil or sildenafil, should not be taken together.

The effects of blood pressure drugs are amplified with Viagra. It also boosts the blood-pressure-lowering effects of nitrates like isosorbide dinitrate, isosorbide mononitrate, and nitroglycerin, mainly used to treat angina. Viagra should not be given to anyone who is taking nitrates.

Viagra should not be combined with PDE5 inhibitors like Vardenafil and Cialis.

Cimetidine, erythromycin, ketoconazole, itraconazole, atazanavir, and mibefradil can significantly increase Viagra levels in the bloodstream. If sildenafil is used, patients taking these drugs should be closely monitored.

Rifampin is likely to lower Viagra levels in the bloodstream, reducing its potency.

Cialis Or Viagra Which One Is More Effective?

Both Cialis and Viagra effectively treat erectile dysfunction, but Cialis may be preferred for its once-daily dosing, and it’s used for treating benign prostate hyperplasia. However, Viagra may be selected for its shorter half-life and used when needed.

Cialis and Viagra were shown to have similar efficacy and safety in a meta-analysis involving 16 separate trials and over 5000 patients. The International Index of Erectile Function (IIEF)-EF scale, extensively used to assess erectile function, was employed to arrive at these conclusions. The incidence of side effects was similar for both medications. On the other hand, Cialis boosted sexual confidence and was chosen over Viagra by individuals who felt less pressured about planning because of its longer-acting effects.

In another study, the active components in Cialis and Viagra were equally effective. Between the two medicines, there were no significant differences. On the other hand, Cialis provided more flexibility because of its longer half-life.

Difference Between Cialis And Viagra

Particulars Cialis Viagra
Generic Name Tadalafil Sildenafil
Treatment It is mainly used for treating benign prostate hyperplasia and Erectile Dysfunction. For Erectile Dysfunction
Dosage It could be taken once daily It could be taken as needed.
After Food/ Empty Stomach Could be taken after food Preferable to take an empty stomach
Half-Life It May last up to 36 hours Shorter half-life.

Both Viagra and Cialis are PDE-5 inhibitors. They relax the smooth muscles in blood arteries that feed the penis. This relaxation boosts blood flow, which aids with erections. However, the active components in Viagra and Cialis are not the same.

Sildenafil is the PDE-5 inhibitor in Viagra, whereas tadalafil is the PDE-5 inhibitor in Cialis. Some guys may react better to one active component than another. However, because sildenafil and tadalafil function through the exact mechanism, the two medications should never be used together.

It would be best if you did not take more than one Viagra or Cialis tablet at a time. Both drugs require sexual stimulation to work. Neither Viagra nor Cialis will create an erection on its own.

Quick FAQ

Can Cialis keep you hard even after coming?
Yes, Cialis usually works for 36 hours and, in some cases, can still keep you hard after ejaculation.
Is any medication stronger than Viagra for ED?
Levitra is approximately 10 times stronger than Viagra in terms of biochemical structure. This results in a lower dosage required to maintain the penile erection.
Is there any fast way to cure ED?
You can potentially cure ED by making healthy lifestyle changes, having medications, surgery, and using vacuum constriction devices, although it is not guaranteed. Counselling also might help in some cases.

Conclusion

Cialis and Viagra are the most commonly prescribed medication for Erectile Dysfunction. Both of the medicines are available only on prescription. Cialis is slightly better than viagra in terms of its duration, while Viagra is somewhat better than Cialis in terms of effectiveness. You can choose either of these medications for your preference and suitability. If you are confused or unsure, consult a healthcare professional.

References