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Clindamycin Cream For Bacterial Vaginosis

clindamycin cream for bacterial vaginosis

Clindamycin was first made from lincomycin in the year 1966. By 2019, it became the 119th most commonly prescribed medication in the US and had 5 million prescriptions. Today, Clindamycin cream is manufactured by Pfizer in the US. Let’s take a look at what Clindamycin cream is and its uses.

Vaginal Clindamycin Cream is used to treat bacterial vaginosis. It belongs to a class of medicines called Lincomycin antibiotics. Bacterial vaginosis is an infection caused by the overgrowth of harmful bacteria in the vagina.

Clindamycin medication is an antibiotic medicine and comes in different forms such as:

  • Capsule
  • Liquid
  • Injection
  • Cream or Gel

Its capsules come in the strengths of 75 mg, 150 mg, 300 mg, and 450 mg.

It’s at a strength of 1% that is the most commonly used. Alternatively, 2% strength of the cream is for more severe discharge cases.

How Does Clindamycin Work?

Clindamycin works by gradually stopping the growth of bacteria. It’s is an antibiotic that can treat various illnesses, including those caused by gram-positive bacteria and those caused by anaerobic bacteria (anaerobic means living without air or oxygen).

It works by stopping bacteria from creating proteins, which stops them from growing. It has a bacteriostatic action, preventing bacteria from multiplying, but not killing them.

Quick FAQ

How do you know when bacterial vaginosis is cleared?
Bacterial vaginosis takes about 2-3 days of antibiotics to clear, but the treatment goes for about seven days at least. It may work slower for some people, though

Who Can Use and Cannot Use it?

Women suffering from Vaginal discharge and bacterial infections can use Clindamycin to treat it. It is only advised to use on girls 12 years of age or older.

Clindamycin cannot treat women suffering from vaginal irritation caused by yeast infections or sexually transmitted diseases like chlamydia and trichomoniasis.

Those who are allergic to the medication must not take it. You must tell your doctor if you ever had these conditions:

  • Colitis, Crohn’s disease
  • Eczema
  • Liver disease
  • Asthma or a severe allergic reaction to Aspirin
  • Allergy to yellow food dye

It is also unclear whether It will harm an unborn baby if taken by pregnant women. It passes into breast milk and may cause side effects in nursing babies.

How to Use it?

Follow your doctor’s instructions when using Clindamycin. Read all drug guidelines or instruction sheets and follow the advice on your prescription label.

It’s oral is a prescription antibiotic that is administered orally. Its injections are given as an infusion in a vein or muscle injection. Your first dosage will be administered by a healthcare professional, who may also instruct you on how to take the drug appropriately on your own.

To avoid irritation of the throat, swallow the pill with a full glass of water.

With liquid medication, carefully weigh it by using a pharmaceutical dose-measuring instrument or a dosage syringe provided (not a kitchen spoon).

During therapy, you may require several medical tests. If you need surgery, inform your surgeon that you are under BV medication as it may interfere with anesthetic medicines.

Even if your symptoms resolve rapidly, take this medication for the whole duration as recommended by your doctor. Skipping the drug can make the infection more resistant to it.


Cream: Use Clindamycin cream 2% one full applicator of (5 g) intravaginally at bedtime for seven days.

Capsules: 300 mg orally two times a day for seven days

Clindamycin Ovules: Use 100 mg intravaginally once at bedtime for three days.

Clindamycin Side Effects

Some women may face side effects during bacterial vaginosis from Clindamycin. Some common side effects are:

  • White patches in the mouth
  • Burning and swelling of the vagina
  • Thick and white vaginal discharge
  • Vaginal pain
  • Nausea
  • Headache

Some adverse side effects are:

  • Diarrhea
  • Fever
  • Stomach pain and cramps
  • Blisters
  • Hives
  • Itching
  • Difficulty breathing

If you face any side effects, we advise you to call your doctor.

Drug Interactions

Clindamycin can react with 82 drugs that are known. It may also react with other medicines not mentioned in this article.

  • Aspirin
  • Fish Oil
  • Flexeril
  • Lyrica
  • Zyrtec

Clindamycin disease interactions include:

  • Prematurity
  • Renal dysfunction
  • Colitis
  • Liver disease


The oral liquid should not be kept in the refrigerator. After two weeks, throw away any unused oral liquid.


A study was conducted at Frauenklink in Munich, Germany, for the efficacy of Clindamycin vaginal cream versus oral metronidazole in treating bacterial vaginosis.

The study’s objective was to compare the efficacy and tolerance of 2%. It’s a vaginal cream compared to metronidazole to treat bacterial vaginosis.

It was a randomized and double-blind study where patients were assigned to 2 ways of treatment on a 1:1 ratio. The patients were seen after 5-10 days and 25-39 days after the therapy.

The effectiveness of oral metronidazole and intravaginal cream was equal at 78 to 83 percent. Both medications were well tolerated, with vaginal infections emerging in 8.5 percent of Its patients and 4.7 percent of metronidazole patients, respectively.

Quick FAQ

Is Clindamycin better than metronidazole for bacterial vaginosis?
There is no significant difference between the efficacy of Clindamycin and metronidazole for the treatment of bacterial vaginosis. Hence, they are both preferable for the treatment.

What are the Alternatives to Clindamycin?

Some other popular antibiotic creams you can take for bacterial vaginosis include:

  • Metronidazole
  • Tinidazole
  • Secnidazole

Always consult your doctor before switching to other medications and follow the guidelines given on the prescription.

How to Get Clindamycin Online?

It is not available over the counter and is only a prescription-based medicine in the United States. You cannot buy the medication online unless you have a prescription or work for a licensed pharmacy.

The cost of Clindamycin typically is the same but may vary depending upon the pharmacy.

Quick FAQ

Why do I keep getting bacterial vaginosis?
Bacterial vaginosis can be caused due to an imbalance of good and harmful bacteria present in a woman's vagina. Having new or multiple sex partners can increase the risk of bacterial infections.


Before using Clindamycin cream, you must take proper care by washing your hands and the area where it has to be applied. You can also use this article to learn more about bacterial vaginosis. It is available without a prescription at local and online pharmacies. However, we also suggest you get advised by your doctor as they know the specific condition of your problem.