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Co-codamol OTC status

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Co-codamol Over The Counter – All Facts You Must Know

Co codamol Over The Counter All Facts You Must Know

Without a doubt, Co-codamol over the counter is one of the most popular products purchased from the pharmacy. Co-codamol tablets can be purchased from a pharmacy without a prescription. Certain supply restrictions apply when co-codamol is bought over the counter.


Co-codamol Over The Counter: Legal Status

Co-codamol tablets available over the counter have the legal status of a pharmacy-only medicine (P). P medicines can only be sold in a pharmacy that operates under the supervision of a pharmacist. This includes online pharmacies.

Over-the-counter Codeine-containing products are restricted to 3-day use only (due to addictive properties); therefore, it is recommended that one pack of Co-codamol can be sold per patient.

Prolonged use of Codeine-containing products or Codeine requires the involvement of a GP and subsequent prescription(s) for the supply. Verbal recommendation from a GP to regularly buy Co-codamol from a pharmacy is not sufficient for frequent requests to purchase this product.

Quick FAQ

Are codeine and co-Codamol the same thing?
Co-codamol is a combination of two medications: Codeine and Paracetamol. Codeine is a 'pain reliever' belonging to the opioid class of drugs. This medication has been prescribed solely to you and should not be given to anybody else.

Co-codamol Over The Counter: Licensed Use

Co-codamol over the counter is licensed for short-term management of acute pains, which other painkillers such as Paracetamol, Ibuprofen, or Aspirin alone are not relieved.

This includes:

  • Headaches
  • Migraines
  • Toothaches
  • Backpain
  • Muscle pain

Over-the-counter codeine-containing products are licensed for adults and children from 12 years of age.

Quick FAQ

Is Codeine an over the counter?
Codeine can only be purchased from a pharmacy in form of codeine linctus (at request). Other options for codeine include combination products with paracetamol (Co-Codamol).

Co-codamol Over The Counter: Active Ingredients

Co-codamol (8/500) which can be bought from a pharmacy contains two active ingredients:

  • Paracetamol (500mg per tablet)
  • Codeine (8mg per tablet)


Most pharmacy chains, including supermarket chains, sell their versions of Co-codamol.

A packet of 32 Co-codamol tablets can be bought for as little as £2.50 (Tesco Pharmacy).

A wide range of branded Co-codamol tablets can be purchased, including:

  • Veganin (vegan Co-codamol), contains 8mg of Codeine, 500mg of Paracetamol and 30mg of caffeine per tablet.
  • Syndol Headache Relief Tablets contains 8mg of Codeine, 500mg of Paracetamol, and 30mg of caffeine per tablet.
  • Solpadeine Plus Tablets/Capsules contains 8mg of Codeine, 500mg of Paracetamol, and 30mg of caffeine per tablet.
  • Paracodol tablets: contain 8mg of Codeine, 500mg of Paracetamol per tablet.
  • Migraleve Yellow Tablets: contains, 8mg of Codeine, 500mg of Paracetamol per tablet.
  • Migraleve Tablets: contain 8mg of Codeine, 500mg of Paracetamol, and 6.25mg Buclizine Hydrochloride (to stop migraine-related nausea)  of Paracetamol and per tablet.

Some branded versions of co-codamol products containing higher amounts of Codeine combined with Paracetamol are available over the counter. For example:

  • Solpadeine Max contains 12.8mg of Codeine and 500mg of Paracetamol per tablet.
  • Panadol Ultra contains 12.8mg of Codeine and 500mg of Paracetamol per tablet.
  • Syndol contains 10mg of Codeine, 500mg of Paracetamol, 30mg of caffeine, and Doxylamine Succinate 5mg per tablet.

Quick FAQ

Is 30mg of Co-codamol strong?
Co-codamol is a combination of two medications: codeine and paracetamol. Codeine is a 'pain reliever' that belongs to the opioid class of drugs. This medication has been prescribed solely to you and should not be given to anybody else.

Co-codamol Over The counter: Formulations

Co-codamol over the counter is available in the form of:

Effervescent tablets dissolve when placed in the water. The Effervescent formulation allows for quicker absorption, hence much faster relief of the symptoms.

Can You Buy Co-Codamol 15/500 And 30/500 Over The Counter?


No. Higher strength of Co-codamol tablets and capsules (Co-codamol 15/500 and Co-codamol 30/500), are available as prescription medications and cannot be purchased over the counter.

Prescription-only Co-codamol is one of the most commonly prescribed drugs in the UK.

How Does Co-codamol Work?

The exact mechanism of action of Paracetamol is not known. Paracetamol has analgesic (helps with pain) and antipyretic properties (reduces temperature). Paracetamol does not have anti-inflammatory properties. Codeine is classified as a weak opioid.

Its analgesic actions are thought to be 1/10 of that induced by Morphine (Mattia & Coluzzi, 2015). Once in the body, Codeine is transformed (metabolized) into different active substances, including Morphine, responsible for analgesic actions.

Generally, drugs work by binding to a receptor. Codeine acts on opioid receptors found in the body, including the brain and gastrointestinal system. Opioid receptors have a role in pain control and transmission.

When Codeine/Morphine binds to target receptors, it stops pain signals from the brain to the affected parts of the body.

Codeine weakly binds to opioid receptors; however, its Metabolite (part of Codeine transformed in the body), Morphine, has a 200-fold better affinity for those receptors (Dean, 2016).

Therefore, the analgesic effects of Codeine depend on how much Codeine is transformed into Morphine in our bodies.

Codeine: Variability In Response

The degree of Codeine metabolism (transformation of Co-codamol to its active form) varies mainly between individuals, meaning that not everyone responds to Co-codamol treatment in the same way.

Some people are poor metabolizers of Codeine; hence they experience little pain relief from Codeine. It is estimated that up to 7% of the Caucasian population are poor metabolizers of Codeine (eMC, 2018).

On the other hand, rapid codeine metabolizers have an increased risk of experiencing side effects of opioid toxicity, including confusion, nausea, vomiting, shallow breathing. Prevalence for rapid metabolizers of Codeine is the highest amongst the African/Ethiopian population, with an estimated 29% of the people affected (ibid).

Concomitant use of other drugs can affect Codeine metabolism; for example, patients on Fluoxetine (a popular antidepressant) can experience fewer benefits (including no benefit at all) in pain management when both drugs are taken together.

Co-Codamol Over The Counter: Possible Side Effects

Patients taking Co-codamol may experience the following side effects:

On prolonged use:

  • Addiction, dependence, and tolerance
  • Worsening of headaches

Why Is Co-codamol Over The Counter Addictive?

Over-the-counter co-codamol should not be used for more than three days at any given time. The UK licensing for all codeine-containing products requires prominent information on the packaging stating, ‘Can cause addiction. For three days use only.’

When taken, Co-codamol can cause a feeling of relaxation, drowsiness, and sometimes euphoria. These are caused by dopamine release within the brain’s reward system.

Repeated use of drugs that have the potential for addiction cause changes to the dopamine system, contributing to addiction, physical dependence, and tolerance (more drug is needed to have the same effect).

Addiction becomes prominent with physical symptoms such as cravings for the drug.

In the case of Codeine, some signs of addiction may include:

  • Anxiety
  • Mood swings
  • Drowsiness
  • Nausea
  • Constipation
  • Dry mouth

Read more on symptoms of codeine addiction on TalktoFrank.

Co-codamol OTC: Alternative Options

Acute pain can be with different over the counter drugs. The choice may depend on the nature of the pain and any underlying health conditions.

Alternative options which should be considered before using Co-codamol over the counter:

  • Use of Paracetamol alone
  • Use of Ibuprofen alone
  • Use of both Paracetamol and Ibuprofen simultaneously (concomitant use of Paracetamol and Ibuprofen may not be allowed in younger patients). Some evidence exists for superior pain relief properties of a combination product such as Nuromol (Paracetamol & Ibuprofen combined) over the use of individual drugs alone in acute pain management. Aspirin 300mg
  • Use of OTC Naproxen (Feminax Ultra) for the management of period pains
  • Use of Sumatriptan in the direction of migraine headaches


Overall over the counter, Co-codamol may provide better pain relief than Paracetamol or Ibuprofen alone. However, patients need to be aware of the side effects associated with Codeine use and its addictive properties.