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How Does Citalopram Make You Feel at First?

how does citalopram make you feel at first

Citalopram is a class of antidepressant medications that treat mental health-related disorders. After taking Citalopram, you may typically feel nauseous on the first day. However, after a few days of medication, the symptoms may increase, and you may feel tired and dizzy to the point that standing up tends to become challenging. Although these side effects disappear after a week, some effects remain, such as nausea, mild dizziness, restlessness, etc.

Citalopram, also known as selective serotonin reuptake inhibitor (SSRI), is a medication usually prescribed for depression to restore the feeling of well-being and increase your overall energy level. In simpler terms, it helps people by correcting their serotonin levels. The FDA first approved Citalopram on 17th July 1998. It can be used on adults and is usually not recommended for anyone under 18. 

After taking Citalopram, the first day goes typically by with a nauseous feeling. However, after a few days of pill consumption, the symptoms increase, and you feel tired and dizzy to the point that standing up tends to become challenging. Although these side effects disappear after a week, some products remain like nausea, mild dizziness, restlessness, etc.

How Does Citalopram Make You Feel And Work?

According to scientists, one of the causes of depression is the imbalance of a neurotransmitter (communicators of the brain) called serotonin. To help people with depression, Citalopram is recommended as it works by preventing such imbalance of Serotonin (mood-enhancing neurotransmitters) after it has been released. Citalopram on the molecular level targets the serotonin transporter preventing its reuptake in the synaptic cleft.

In simple terms, Citalopram works by increasing the levels of Serotonin(also considered a hormone) which is a feel-good hormone that prevents anxiety and depression.

Forms and Strengths of Citalopram


Citalopram is available in the form of a tablet and oral solutions.

Strength: Tablets are available in 10,20, and 40mg forms.

Oral solutions are available in 10mg/5ml.

How to Take Citalopram?

Citalopram is supposed to be taken only once a day. This would not affect the medicine, whether it’s with or without food.

One can take Citalopram at any time of the day, but one should note that it will only be taken simultaneously every day. If the patient has trouble sleeping, it should be taken in the morning.

Common Side Effects:

Following are the common side effects:

  • Diarrhea
  • Nausea
  • Constipation
  • Weight loss
  • Yawning
  • Weakness
  • Heavy menstrual periods etc

There are specific Serious side effects which include:

  • Chest pain
  • Loss of Breathing
  • Fever
  • Coma
  • Loss of Coordination
  • Irregular heartbeat etc

One should get emergency medical help after noticing any of these side effects to prevent further risk to the health.

Who Should Not Take it?

Patients with congenital long QT syndrome are recommended not to take this medicine as this might further worsen the situation; patients with low potassium and magnesium levels are not allowed to take it as it increases the risk. If anyone consumes Citalopram as a dosage of 40mg/day, they should seek professional advice.


Citalopram is a medicine supposed to be taken once a day and in between proper intervals only. Hence caution should be taken that doses are not brought together, and there is enough time between two quantities. Doing so may lead to confusion, restlessness, agitation, and many other symptoms. Also, alcohol consumption and other illegal substances must be prohibited when Citalopram has been prescribed.

Drug Interactions:

After the medicine is prescribed, do not change or modify the dosage without consulting your doctor first. Other than that, your doctor will already be aware of drug interactions with Citalopram and can be consulted for the same.

A few Medicines that can have severe interaction with Citalopram include:

  • dronedarone
  • ziprasidone
  • selegiline
  • isocarboxazid
  • procarbazine phenelzine
  • pimozide
  • selegiline transdermal
  • tranylcypromine

Note: Citalopram interacts with 79 drugs with up to severe symptoms, whereas 208 medicines have moderate interactions with Citalopram.


To conclude, Citalopram is a medicine used to cure depression, and it comes in many forms and dosages. Consult your doctor to know which dosage you should take or if you wish to modify your dosage. Do not act on your own because an overdose of Citalopram has many severe side effects. At first, the medication will weaken your body, which will disappear after the first week but might still return.