Post Highlights

Can I Take Naproxen And Paracetamol Together

Can naproxen and paracetamol be taken together?

No matter what happens, what medicines you are taking yourself, even if it’s ‘Ayurveda’ or medicine having a lesser impact, it is always recommended to ensure that your doctor knows about it. Every medication can have a slightly different impact differing from person to person. Ensure any combination of medicine is comfortable for you.

Today we will talk about the specific combination of drugs and if they have any side effects and what happens if we take naproxen and Paracetamol together.

Before that, let’s understand what Naproxen and Paracetamol are.


What Is Paracetamol?

Paracetamol is a pain reliever medicine. It’s simply a pain killer. It is hard to understand the mechanism of action for the same medicine yet, but it works on body pain or any pain very well.

Paracetamol medicine is used for headaches, muscle aches, arthritis, backache, toothaches, colds, and fevers; it makes the pain in mild arthritis disappear but has no side effect on the underlying inflammation and swelling the joints. Let’s see in detail in what conditions paracetamol works.

Paracetamol is used for the treatment of various conditions, including:

Uses of Paracetamol

Fever is elevated body temperature. This is because of environmental conditions or any underlying medical condition. Paracetamol is one of the highly recommended medications to reduce fever. paracetamol provides temporary relief from fever without treating the original problem

Headaches are extremely common in adults. It is usually relieved by medications, food, caffeine intake, some resting time, and relaxation techniques, like breathing, meditation, etc. Paracetamol is the most preferred over-the-counter pain reliever used to treat headaches.

Muscle Pain
Muscle aches can be painful and distressing and limit you from doing everyday chores. It can occur due to stress, tension, vigorous physical activity, or medical conditions. Paracetamol helps to ease mild to moderate pain in the muscles. Your doctor may prescribe this medicine alone or in combination with other medication if the pain is severe.

Menstrual Cramps
Menstrual cramps are cramping pains in the lower abdomen. Many women have menstrual cramps just before and during periods. Paracetamol is used for the treatment of muscle cramps and pain during periods.

Joint pain or discomfort
Joint pain occurs due to damage to the joints because of injury or medical conditions like osteoarthritis, rheumatoid arthritis, bursitis, gout, strains and sprains. Mild joint pains can be relieved by Paracetamol. However, your doctor may prescribe this medicine and other medications if the pain is severe.

A toothache or tooth pain is a sharp pain that you feel in or around your tooth. Paracetamol helps to relieve toothache to an extent. But Paracetamol cannot treat severe toothache. Visit your nears dentist to find the exact cause of toothache.

Post Vaccination Fever
Vaccinators provide paracetamols to treat fever, local pain, and swelling that sets in after a vaccine has been administered.

What is Naproxen?

Naproxen is a commonly prescribed Nonsteroidal Anti-Inflammatory (NSAID) Drug. In 2018, Naproxen was prescribed more than 7 mln times (OpenPrescribing.net, 2019), making it one of the most commonly prescribed drugs in the UK.

Naproxen is used for the treatment of various conditions including:


  • Rheumatoid arthritis
  • Osteoarthritis
  • Gout
  • Acute musculoskeletal (muscle & bone) problems
  • Dysmenorrhoea

The ability of NSAID to help with analgesia inflammation and produce antipyretic effects comes from inhibition of cyclo-oxygenase-1 (COX-1) and COX-2 enzymes. COX 1 and COX 2 enzymes are responsible for synthesizing prostaglandins, which are produced in response to injury or infection (BMJ, 2013). One subtype of prostaglandins acts on ‘sensory neurons,’ resulting in pain (Ricciotti & FizGerald, 2011).

Naproxen is one of the first choices when NSAIDs are considered in prescribing. This is because Naproxen has good efficacy and low side effects but is higher than ibuprofen (BNF, 2019).

Patients should benefit from pain relief straight away after taking the first dose of Naproxen. However, it may take a week to achieve full pain relief, whereas maximum anti-inflammatory effect may not be achieved up to three weeks after starting the treatment (ibid).

Quick FAQ

Can I take Naproxen at bedtime?
The standard naproxen sodium - diphenhydramine dosage is two tablets (each containing 220 mg naproxen sodium and 25 mg diphenhydramine) given by mouth before sleep. In any 24 hours, no more than two tablets should be taken. This drug can be taken on an empty stomach or with food.

Why can't you lay down after taking Naproxen?

After taking this medication, do not lie down for at least 10 minutes. The dosage is determined by your medical condition and treatment response. Take this drug at the lowest effective dose for the shortest time feasible to minimize the risk of stomach bleeding and other adverse effects.

Can I Take Naproxen And Paracetamol Together?

Naproxen and paracetamol can be taken together. Both drugs can help with the pain. However, only Naproxen works to reduce inflammation. Paracetamol does not have anti-inflammatory properties and does not belong to a NSAID class of drugs.

Furthermore, summary product characteristics (SPC) for Naproxen do not indicate any interactions between Naproxen and paracetamol.

Quick FAQ

How long after Paracetamol can you take Naproxen?
Oral painkillers can take up to 45 minutes to begin functioning. Before taking any more paracetamol or codeine, wait at least four hours. Between Naproxen dosages, wait 12 hours. Keep track of the painkillers you have taken.

What Other Painkillers Can Be Taken With Naproxen?

What Other Painkillers Can Be Taken With Naproxen

Opioids such as codeine, tramadol or morphine and other codeine-containing products such as co-codamol (paracetamol and codeine) can be taken together with naproxen.

Occasionally Diazepam and Naproxen is prescribed together with co-codamol.

What Should Not Be Taken With Naproxen?

Other NSAIDS such as aspirin, ibuprofen, and combination products containing ibuprofen (for example, Nurofen Plus: codeine and ibuprofen) should not be taken with Naproxen unless advised by your GP.
Certain medical conditions require some patients to take a low dose of aspirin 75mg, and in those circumstances, concomitant use with Naproxen may be permitted by their GP.

Quick FAQ

Can I take 2 Naproxen 500mg at the same time?
Adults— Once a day, take 750 milligrams (mg) (one 750 mg or two 375 mg pills) or 1000 milligrams (two 500 mg tablets). If necessary, your doctor may change your dose. However, the daily amount is normally limited to 1500 mg (two 750 mg or three 500 mg pills).


As we always recommend, do not take any medication without consulting your certified doctor. Do not take naproxen with ibuprofen or any other non-steroidal Anti-inflammatory drugs (NSAIDs). But it is okay to take paracetamol with naproxen or co-codamol that you buy over the counter. Research hasn’t found any harmful effect on one’s body, but it is recommended to be for a short time only.

If you feel like taking extra pain killers together, naproxen and paracetamol and other similar drugs for a more extended period, please consult your doctor. Sometimes it is okay to take different medications together, and they will work for a shorter period. But there might be other treatments that you can apply for and opt for.