Nuromol: paracetamol and ibuprofen together in one product
Drug reviews

Nuromol review

In the latest post, Nuromol review, I will look whether taking Nuromol drug (combination of ibuprofen and paracetamol) is more effective in reducing pain than taking ibuprofen and paracetamol alone. Priced well over £6 for 24 tablets, one must wonder ‘is it worth the money?’

Both ibuprofen and paracetamol can be purchased at a considerably lower price when bought individually.

Nuromol review: the product

Nuromol is a Pharmacy only medicine (P) containing two active ingredients ibuprofen and paracetamol:

  • Ibuprofen 200mg per tablet
  • Paracetamol 500mg per tablet

What can Nuromol be taken for?

Nuromol is indicated for the management of mild to moderate pain associated with headache, migraine, backache, dental pain, muscular pains, sore throat, fever and cold, and flu symptoms.

Nuromol mode of action

Ibuprofen belongs to a group of medication called nonsteroidal anti-inflammatory drug (NSAID). It has fever and pain reducing properties. It stops the production of certain ‘chemical’ in the body which are responsible for inflammation and swelling.

Paracetamol has both antipyretic (reduction of fever) and analgesic properties (reduction of pain). Unlike ibuprofen, paracetamol does not reduce inflammation.

Combination of ibuprofen and paracetamol has its advantages. Two different drugs act in synergy to give pain relief and anti-inflammatory actions.

This is a great alternative to other pharmacy only combinations products such as co-codamol, which is associated with the number of adverse side effects, tolerance, dependence and risk of addiction.

Nuromol review of effectiveness.

Is Nuromol better than taking ibuprofen and paracetamol alone?

Efficacy of Nurmol is confirmed with different clinical trials. Without going into details, two well designed clinical studies involving post-operative dental patients confirmed that:

  • A dose of two Nuromol tablets is significantly superior to a dose of 400mg of ibuprofen or 1000mg of paracetamol when taken alone (at 30 minutes post-dose and from 2-4 hours post-dose)
  • A dose of one Nuromol tablet (ibuprofen 200mg & paracetamol 500mg) was significantly superior to 1000mg paracetamol, but not to 400mg of ibuprofen in management of pain.

One study of 688 patients found that Nuromol (dose of two tablets) was statistically more effective than combined ibuprofen 400mg and codeine (25.6mg) and more efficacious than a dose of combined paracetamol 1000mg and codeine 30mg.

No new adverse side effects for Nuromol were observed in studies other than those known for ibuprofen and paracetamol monotherapies. Some common side effects reported included abdominal pain, diarrhoea, dyspepsia, nausea, stomach discomfort and vomiting (Barnard, ND). Read product information leaflet to read more about potential side effects.

Details of all studies can be found in MHRA’s Public Assessment Report on Nuromol.

Why is Nuromol more effective than paracetamol and ibuprofen monotherapies?

Many customers (like me) may feel sceptical about Nuromol possibly due to the significant price difference between Nuromol and individual prices of ibuprofen and paracetamol. However, information from clinical trials comparing Nuromol to ibuprofen and paracetamol show that taking Nuromol is more effective in reducing the pain than equivalent doses of ibuprofen and paracetamol alone.

Why is Nurmol more effective?

Nuromol formulation is designed to allow simultaneous release and absorption of both ingredients providing for better combined analgesia (Tanner et al, 2010). This contrast to paracetamol and ibuprofen which dissolve at a different pace, and therefore cannot provide for the same analgesia even when taken at the same time as individual drugs.

Studies have confirmed that Nuromol dissolves 2-3 times faster than standard ibuprofen and paracetamol tablets.

Overall, Nuromol is a great alternative to ibuprofen and paracetamol drugs. Nuromol may provide a better pain relief than both individual drugs or other combination products available in the pharmacy.

References:

Barnand John (ND). Research review. Nuromol for acute relief of pain and/or inflammation and reduction of fever. Available at: https://www.researchreview.co.nz/getmedia/48a554e1-1c22-40ef-96e4-abf48d214429/PR_Nuromol.pdf.aspx?ext=.pdf Accessed on 13/05/2019

Tanner T, Aspley S, Munn A, Thomas T. The pharmacokinetic profile of a novel fixed-dose combination tablet of ibuprofen and paracetamol. BMC Clin Pharmacol 2010;10:10. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906415/ Accessed on 13/05/2019

 

I am a community pharmacist working in UK. I blog about drugs, health and pharmacy.

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