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Paroxetine for Premature Ejaculation

paroxetine for premature ejaculation

Premature ejaculation is a common sexual condition in males that affects up to 30% of men in their sexual lives. Many psychotropic and antidepressant medicines, which operate centrally or locally to delay the psychoneurological regulation of ejaculation and consequent orgasm, cause delayed ejaculation as a side effect. Serotonin, a central neurotransmitter, has an inhibitory influence on sexual activity in humans and animals, whereas dopamine is generally stimulatory.

Any change in the serotonin-dopamine balance caused by increasing or reducing one or both neurotransmitters might cause sexual effects. Serotonin reuptake inhibitors (SSRI) diminish sexual excitement and help with premature ejaculation.


Paroxetine For Treatment Of Premature Ejaculation

Paroxetine is a medicine that belongs to the selective serotonin reuptake inhibitors (SSRIs) class of drugs. Paroxetine is a common antidepressant in the UK. It is a long-acting SSRI often used to treat depression and other mood disorders. On the other hand, Paroxetine has also been clinically demonstrated to be an effective treatment for premature ejaculation at lower levels than for mood disorders. Paroxetine is a 20mg oral tablet taken daily or as needed. For the treatment of premature ejaculation, Paroxetine is recommended in doses ranging from 10 mg to 40 mg.

How Paroxetine Works

Paroxetine is an SSRI that is used to treat Premature Ejaculation symptoms off-label. SSRIs function by boosting serotonin levels in the brain in general. Serotonin has an impact on mood, emotion, and sleep. Paroxetine can help regulate and delay ejaculation by reducing serotonin reuptake.
Paroxetine, when taken daily, can aid in the treatment of Premature Ejaculation in men of all ages.

Paroxetine Side Effects

Paroxetine, like all drugs, has the potential to cause adverse effects. The following are the most prevalent mild side effects:

  • Nausea
  • Headaches
  • Dizziness
  • Drowsiness

Some of the severe side effects are:

  • Fainting
  • Seizures
  • Blurred vision

Paroxetine In Comparison To Other Premature Ejaculation Treatment

Paroxetine Vs. Dapoxetine

Paroxetine and Dapoxetine (Priligy) belong to a class of selective serotonin reuptake inhibitors(SSRIs). Dapoxetine is the only short-acting SSRI that is particularly given for premature ejaculation. Priligy can be taken 1 to 3 hours before intercourse on an as-needed basis. According to clinical trials, Priligy is a safe and effective option; read Priligy’s review to know how much is effective. Researchers have found Paroxetine to show better results in delayed intravaginal ejaculation latency than Dapoxetine. However, both drugs are usually well tolerated.

Priligy cannot be purchased online since it is a category IV medicine that can only be obtained with a prescription. It is critical to determine if someone is a good candidate for Priligy. Priligy is a schedule IV medication. If you want to buy Priligy, you must have a prescription.

Paroxetine Vs. Fluoxetine

Fluoxetine (Prozac) and Paroxetine are examples of long-acting SSRIs. These medications for premature ejaculation are provided at a lesser dose than antidepressants or other mood disorders. They are, nevertheless, extremely successful at delaying and controlling ejaculation. Both are well-tolerated and have been clinically demonstrated to alleviate the symptoms of premature ejaculation. Hence, they are prescribed as off-label medications for patients that experience premature ejaculation.

It is important to remember that everyone is different. Varying medications may cause different reaction responses.

Precautions To Be Taken While On Paroxetine


Paroxetine’s nervous system side effects, such as dizziness, drowsiness, and problems concentrating, might be exacerbated by alcohol. Some people might have difficulty in thinking and making decisions. While taking Paroxetine, you should avoid or minimize your alcohol use.

Monoamine Oxidase Inhibitors

Isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, and tranylcypromine are all examples of monoamine oxidase inhibitors. Do not start taking Paroxetine for at least two weeks after discontinuing a monoamine oxidase inhibitor intake. Likewise, do not start taking a monoamine oxidase inhibitor for at least two weeks after stopping Paroxetine. If you take them together, you may get disorientation, agitation, restlessness, stomach or intestinal symptoms, a very high body temperature, excessively high blood pressure, severe convulsions, or do not wait for at least two weeks before taking either.

Other Medicines

Paroxetine is used with other medications, and it might produce a dangerous illness known as serotonin syndrome. Avoid taking Paroxetine with buspirone, fentanyl (Duragesic), lithium carbonate (Lithobid), tryptophan, St. John’s wort, amphetamines, or pain relievers such as rizatriptan (Maxalt), sumatriptan (Imitrex), tramadol, and frovatriptan (Frova). Before taking any additional medications with Paroxetine, see your doctor.

This medication may reduce men’s sperm production and thus their ability to produce children. Consult your doctor before using this medication if you plan to have children.

Other than that, Paroxetine may cause agitation, irritability, or other aberrant behaviours in teenagers and young adults. It may also lead to suicidal ideations and behaviours and a worsening of depression in certain people. Some people may have difficulty sleeping, become quickly irritated, gain a lot of energy, or become irresponsible.

Tyramine-Rich Foods

Interactions between Paroxetine and tyramine-rich foods such as cheese, milk, beef, chicken liver, meat extract, avocados, bananas, tinned figs, soybeans, and too much chocolate can cause severe spikes in blood pressure.


Paroxetine can be used to treat premature ejaculation if used safely. Men having a history of depression or other mental health illnesses, low blood pressure or other heart problems, liver difficulties, or renal problems may not be able to use it. Paroxetine should not be combined with any mood-controlling drugs, such as antidepressants. It is essential to provide your doctor with as much accurate medical information as possible so that they can provide the best treatment options for you.

Always use the medicine as prescribed by the consulting doctor.