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Promethazine For Comfortable Sleeping Treatment

promethazine for sleep

Promethazine belongs to the class of drugs called phenothiazines. Promethazine is an antihistamine and antipsychotic to treat allergies, insomnia, and nausea. Its use as an antipsychotic is not so common anymore. It is also used to treat allergic conjunctivitis symptoms, hay fever, and different types of allergies or allergic reactions. It is a prescribed medication that comes in various forms like a tablet, a capsule, an injectable solution, a rectal suppository, and an oral solution (syrup). Promethazine is a very effective over the counter OTC sleeping pill.

The FDA approved promethazine in 1951. Promethazine and its antihistamine properties were discovered in France in 1946. It was named “Phenergan,” and it was found by Halpern, while two years before that, in 1944, dr. David Stanley and Henry Gilman had reported the synthesis of promethazine.

Promethazine For Sleep

Promethazine is a drowsy/sedating antihistamine; hence it would cause sleepiness more than other antihistamines.
Promethazine is mainly used in treating sleep disorders like insomnia, including being awake due to coughing or pruritus. It can also be used to succeed in sedation before and after surgery.
To be effective when taken as a tablet or capsule, it should be administered 30 minutes before going to sleep since it takes around 20 minutes to work. This medication is suitable for short-term sleep problems.

How Does It Work?

Promethazine works by restricting the release of histamine from cells. Hence it is an antihistamine substance. Histamine is released in response to substances that act as allergy triggers. When released by the cells, histamine can trigger cognitive ability and wakefulness, resulting in our senses being more heightened and responsive. Promethazine prevents the release of histamine, resulting in feeling tired and exhausted, and it can also help in pain management. Moreover, vomiting and nausea Promethazine is known to affect serotonin and dopamine levels as well.

What Does Promethazine Treat?

Following, we describe the conditions that Promethazine helps treat:

Motion sickness:

Promethazine is helpful to tackle motion sickness while traveling and vertigo.

Insomnia:

Promethazine aids in short-term sleep problems. If you take this medicine before bedtime, it will help you sleep well. Frequent use is avoided since it can induce side effects. Sometimes, it can make you tired during the day as well.

Feeling Nauseous:

Promethazine is also indicated to prevent and control vomiting.

Symptoms of allergies:

Promethazine is an antagonist of histamine, so it blocks histamine and its actions. This results in relieving hence the symptoms of allergies, including skin rash, running nose, and itching, which are allergic reactions.

Anxiety before a surgery:

Taking Promethazine a night before the surgery can help control anxiety, which would result in not worrying about the surgery. The less you stress, the more relaxed you go into the process.

Pain after surgery:

Promethazine can also manage, to an extent, pain after the surgery. Taking 50mg the night before surgery; 25mg to 50mg after surgery should manage the pain.

Promethazine can also be a part of combination therapy, i.e., it can be used with other drugs. This is mainly to treat flu-like symptoms; your dose will depend on your doctor’s prescription and the kind of medicine you’re taking.

Promethazine Study

A study was conducted to know the effects of Promethazine on nocturnal sleep in normal men.

10 healthy volunteers were under observation in two double-blind polygraphic studies to know about the effects of a Phenothiazine. This study, divided into two parts, examined the use of promethazine as a single dose, in different dosages (50, 100, and 200mg), using 100mg of phenobarbital as a reference substance in the first part. In the second part, the effect of promethazine was studied(100mg) on 4 subjects who spent 20 continuous nights with 9 nights given the drug, followed by a placebo withdrawal-induced period of 6 nights.

Promethazine showed a depressing effect onREM cycle which was positively correlated to the dosage; the higher the dose of promethazine, the more depressed the REM cycle. When used in its highest dose, i.e., 200mg, promethazine caused drowsiness and gave hangover-like effects on 14 nights out of 20.

Promethazine Dosage

The dosage will be different from patient to patient and depends on the condition. . Following are different doses applied for other conditions:

Allergy Symptoms:

Adults and teenagers: 12.5mg before meals and at bedtime; or 25mg once at bedtime as per your needs.

Children 2 years and older: The doctor will determine the dose. The dose is usually 6.25mgto12.5mg thrice a day, or 25mg at bedtime as per your needs.

Children 2 years and younger:  Contraindicated. Consult your doctor.

Prevention Of Motion Sickness:

Adults and teenagers: 25 mg daily; the starting dose should be 30 to 60 minutes before travel. It can be repeated after 8-12 hours. 25mg can be retaken before an evening meal.

Children 2 years and older: The doctor will determine the dose. The dose is usually 12.5mg to 25mg 30 to 60 minutes before traveling; the dose can be repeated every 8-12 hours if needed.

Children 2 years and younger: Contraindicated. Consult your doctor.

Nausea And Vomiting:

Adults and teenagers: The first dose should be 25mg, followed by 12.5 to 25mg of doses repeated every 4 – 6 hours if needed.

Children 2 years and older: The weight and size are taken into consideration by the doctor to determine the dose. The dose is 0.5mg per pound of body weight or 12.5 to 25mg every 4-6 hours per your needs, and it should not exceed 25 mg.

Children 2 years and younger: Contraindicated. Ask for your doctor’s advice.

Sedation:

Adults and teenagers: 25mg to 50mg.
Children 2 years and older: The weight and size are taken into consideration by the doctor to determine the dose. The dose is usually 12.5 to 25mg.

Children 2 years and younger: Contraindicated. Consult your doctor.

Control of pain and anxiety before and after surgery:

Adults and teenagers: 50mg the night before surgery; 25mg to 50mg after surgery.

Children 2 years and older: The weight and size are taken into consideration by the doctor to determine the dose. The dose is 12.5 to 25mg the night before or after the surgery.

Children 2 years and younger: Contraindicated. Ask for your doctor’s advice.

Possible Side Effects

Feeling drowsy:
Promethazine blocks the histamine from the body, which results in feeling drowsy.

Dizziness

Promethazine could make you feel dizzy and have blurry vision. This could also be an underlying effect of mixing alcohol with the medication.

Allergic reactions:
People who are allergic to any inactive ingredient present in the medicine could form allergies. Skin rash, coughing, and itching are some allergic reactions that may result from taking Promethazine.

Drug Interaction

Ambien:
Using Promethazine can cause side effects like dizziness, difficulty in thinking, and drowsiness.
Benadryl:
Using this drug with Promethazine can cause side effects like sedation, drowsiness, blurred vision, dry mouth, and hypoglycemia which is an emergency. Ask for your doctor’s advice.
Flexeril:
Using this drug with Promethazine can have side effects like sedation, drowsiness, blurred vision,
Lexapro:
Using this drug and Promethazine can increase the risk of an irregular heartbeat that could be life-threatening. Promethazine and Lexapro can increase your serotonin levels and lead to a life-threatening syndrome called a neuroleptic-malignant syndrome. Always consult your physician.
Topamax:
Topamax can have side effects like increased body temperature and decreased sweating; when taken with Promethazine, it can worsen these side effects.
Xanax:
Using Promethazine can lead to side effects like dizziness, difficulty in thinking, and drowsiness.

Other drugs can interact with Promethazine, which is not mentioned in this article. Feel free to consult your doctor for further doubts since some medicines are strictly contraindicated.

Precautions

Before using this medication, the following should be considered:

Allergies:

Before using this medication, make sure to read the description of the medicine carefully and see if you are allergic to any of the ingredients. Before using this medication, please consult your doctor and disclose all known allergies to him.

Pediatric:
This medicine’s safety and regulatory use have not been established in children 2 years and older. Consult your doctor beforehand.

Geriatric:
The side effects of this medication could be more effective for the elderly, which may require an adjustment in their doses.

Breastfeeding and pregnancy:

There is no evidence that promethazine is present in breast milk. Consult your doctor if you breastfeed and need to take this medication. There is no evidence concerning pregnancy safety, but it is considered safe to use after consulting your doctor. Do consult your doctor before consuming this drug while pregnant.

With alcohol:
Consuming this drug with alcohol could make you even more tired. Hence it isn’t advised to do so.

For people with heart problems:
People with a heart condition could face adverse effects like the irregular rhythm of the heartbeat.

Alternatives:
Following are the other options for Promethazine:

Ondansetron:
This drug is prescribed for Nausea and Vomiting. It is also used for chemotherapy/Radiation-induced nausea and vomiting. Off-label, it is also prescribed for alcohol dependence, OCD, etc.

Zofran:

This drug is prescribed for Nausea and Vomiting. It is also used for chemotherapy/Radiation-induced nausea and vomiting. It can also be given to children for headaches, dehydration, and suspicion of acute gastroenteritis.

How To Get It Online?

Promethazine is available across many online E-commerce platforms. Websites that answer queries and questions about Promethazine could also be a source of getting it online. You can search on google for your questions and get them resolved quickly.

Quick FAQ

Does Promethazine cause weight gain?
Yes, in some cases, it does.
Is it safe to take Promethazine every night?
This medication is for short-term sleeping problems. It should not be taken more than 7 days without talking to your doctor.
Should you take Promethazine on an empty stomach?
Promethazine can be consumed with or without food as advised by your doctor.

Conclusion

Promethazine may relieve allergic symptoms, aid sleep, reduce anxiety and pain before and after surgery, and treat motion sickness-induced nausea and vomiting. Promethazine is an antihistamine that belongs to the drug class called phenothiazines. Side effects include feeling drowsy, sedated, and sleepy. The drug is available in a tablet, capsule, syrup, injectable dose, and a suppository. Do consult your doctor before taking this drug.

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