15 Best RANITIDINE Alternative Drugs

15 Best RANITIDINE Alternative Drugs

Ranitidine can be a solution to treat heartburn and indigestion. What if you do not get the same medicine? So here are the 15 alternatives you can choose to treat the condition.

February 07, 2020
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Post Highlights

Ranitidine alternative drugs are in demand. It is logical to consider an alternative rather than buy Ranitidine. UK markets have been wiped out from Ranitidine, a popular medication used mainly in the management of indigestion / acid reflux.

In the US and UK, Ranitidine was subject to a number of recalls at the end of 2019 and the beginning of 2020 due to possible contamination with N-Nitrosodimethylamine (NDMA), a probable human carcinogen (a chemical that possibly causes cancer).

The topic of Ranitidine and cancer risk with updates on all Ranitidine recalls was previously discussed in the post: Ranitidine recalls - updates & patients information.

Ranitidine Drug Classification

Ranitidine belongs to a group of medicines called H2-receptor antagonists, commonly known as H2-blockers.

Although as complicated as it may sound, the meaning behind this definition is straightforward:

  • H2 is a type of receptor located in the stomach lining
  • Receptor is a molecule that has a role of a port to which other molecules, including drugs, can bind
  • An antagonist is a chemical or drug which binds to a receptor and stops some biological action from happening In relation to this post, the secretion of stomach acid is reduced when Ranitidine binds to an H2 receptor
Overnight, ranitidine reduces gastric acid output and prevents esophageal acid exposure.
To treat stomach ulcers, take the following steps: Adults: Take 40 milligrams (mg) before a meal once a day. If necessary, your doctor may change your dose.
Those who take ranitidine or Zanac OTC are not recommended to take the drug for more than two weeks. Unless your doctor advises you otherwise, we suggest you avoid taking it for long-term use.
Taking ranitidine at night decreases gastric acid secretion and eliminates esophageal acid which prevents acidity.
There is no proof of any study indicating that ranitidine affects your heart for the long term. However, it can affect your heart for a short period of time. Unexpected changes in heart rhythm can be experienced in the short term.
When you have symptoms or suspect you will, take antacids as soon as possible. For most individuals, the ideal time to take them is with or shortly after meals.

Ranitidine Alternative Drugs: Classification

Over the counter (OTC) or prescription-only medications (POMs), which can be used as an alternative to Ranitidine, belong to one of the following groups:

  • (other) H2-receptor antagonists (same drug class as Ranitidine)
  • Proton pump inhibitors (PPIs), for example, omeprazole or esomeprazole
  • Antacids

From a legal perspective, drugs alternative to Ranitidine are available as products licensed according to one of three categories:

  • Over-the-counter options are also known as Genera Sale List (GSL) items. GSL products can be sold in any retail outlets such as supermarkets, shops, etc
  • Pharmacy-only medicines (P) are only available from pharmacies or online pharmacies that operate under the supervision of a pharmacist
  • Prescription-only medicines (POMs) are available only on prescription, written by a doctor or any other qualified prescriber

 Gastro-Oesophageal Reflux Disease (GORD) Is Explained (video)

To understand even more the treatment used in the management of GORD< i strongly recommend watching the video below.

Ranitidine Alternative Drugs: Over The Counter Products

Over The Counter H2-receptor Antagonist

In the UK, Ranitidine is the only H2-receptor antagonist available over the counter. Over-the-counter Ranitidine is available in different brands, with Zantac being the most popular. Most large pharmacy chains (Lloyds, Boots) and supermarkets (Tesco, Asda) sell their version of Ranitidine.

All Ranitidine products available for the public to buy contains 75mg of Ranitidine per tablet. Ranitidine and Zantac most likely will not be available over the counter in the nearest future due to safety issues, as highlighted by a number of recalls for this drug.

Over The Counter Proton Pump Inhibitors As An Alternative To Ranitidine

There is a number of PPIs available to buy without a prescription from the pharmacy (P) or simply off the shelf in supermarkets or other retail outlets (GSL).

PPIs are more effective in reducing acid production than H2-receptor antagonists such as Ranitidine; however, they are associated with the possibility of more common side effects and a number of possible interactions with other medicines. If in doubt, read the product information leaflet or speak to the pharmacist before using a PPI.

Over the counter PPIs: cautions in use

All over the counter PPIs have similar licenses and recommendations on the duration of treatment:

  • All PPIs available without prescription are licensed for adults aged 18 years and over
  • Over-the-counter PPIs ad are generally used in the short-term management of heartburn / acid reflux
  • If symptoms do not resolve within 14 days of the treatment with over-the-counter PPIs, patients are advised to speak to their GP
  • For all PPIs, some patients may need to take the medication for 2-3 days before improvement in symptoms is seen; however, some may experience relief from symptoms on day 1. Nevertheless, over-the-counter PPIs are not advertised as products for the immediate release of heartburn symptoms

PPIs common side effects

Common side effects associated with the use of PPIs:

  • Upset stomach: diarrhea, constipation, flatulence (wind)
  • Vomiting (being sick) or nausea (feeling sick)
  • Headache
  • Formation of benign polyps in the stomach

Over the counter PPIs: Interactions with other drugs

Please refer to the product information leaflet or speak to the pharmacist if you take any other medication.

Esomeprazole Products Alternative To Ranitidine

The main active ingredient of the next two products is esomeprazole. Like omeprazole, esomeprazole is a proton pump inhibitor. Similarly, patients may need to take esomeprazole for 2-3 consecutive days to control their symptoms, although a single dose of esomeprazole may provide relief from symptoms of acid reflux.

If no improvement in symptoms is seen within two weeks despite the treatment with esomeprazole, patients need to speak to their GP.

1. Nexium Control (Esomeprazole)

Availability: GSL - any retail outlet or website, supermarkets, and pharmacies.

Dose: the recommended dose is one capsule/tablet per day

Nexium Control contains 20mg of esomeprazole as an active ingredient. A single dose of Nexium Control can settle the symptoms of heartburn for up to 24 hours.

Read Nexium Control review to learn more about this medication,

including common side effects, drug interactions, and information about the effectiveness as compared to omeprazole drug.

Nexium Control is widely available; most supermarkets and pharmacies stock this product. It can also be bought online from different websites, including Amazon.co.uk.

Nexium Control comes in the form of capsules and tablets, available in two different pack sizes of 7 and 14 tablets. Nexium Control capsules are advertised.

2. Guardium Acid Reflux Control (Esomeprazole)

Availability: GSL - any retail outlets or websites, supermarkets, and pharmacies. Dose: the recommended dose is one tablet per day (20mg of esomeprazole daily) for up to two weeks.

Guardium Acid Reflux Control also contains esomeprazole as an active ingredient.

It is the latest addition of esomeprazole-containing products available without a prescription in the UK. Guardium Acid Reflux Control can be purchased online.

It is a GSL product, and therefore within the next few months, one would expect it to be available in supermarkets and pharmacies.

Guardium Acid Reflux Control is promoted as a product from the makers of Gaviscon, a popular brand of a wide range of antacid medications used in the symptomatic management of heartburn. Guardium Acid Reflux Control comes in a pack size of 7 and 14 tablets.

3. Galpharm Esomeprazole Capsules

Recently launched in Tesco, Galpharm Esomeprazole offers one of the cheapest options when it comes to PPIs.

Galpharm Esomeprazole comes in two different pack sizes: 14 capsules (£10.00) and 7 capsules (£5.90)

both available on the shelf in the medicines aisle located in the main part of the store (not in the pharmacy).

Omeprazole As An Alternative To Ranitidine

4. Omeprazole 10mg Gastro-resistant Tablets

Availability: Pharmacy-only medication.

Dose: The recommended dose is 20mg daily  (Two 10mg tablets) for up to 14 days.

Omeprazole is available as pharmacy-only medication in the form of 10mg gastro-resistant tablets. Large pharmacy chains mainly sell omeprazole 10mg under their own brand name, for example, Boots Acid Reflux 10 mg Gastro-Resistant Tablets (Boots Pharmacy) and Lloyds Pharmacy Heartburn Relief 10mg Tablets.

5. Pyrocalm Control (Omeprazole)

Availability: GSL medication - any retail outlet or website, supermarkets, and pharmacies. Dose: 1 tablet taken once daily for a recommended maximum of 14 days.

Available as a GSL product, each Pyrocalm Control tablet contains 20mg of omeprazole.

Pyrocalm Control was launched in 2019, and it is still a relatively new product. Not all pharmacies or supermarkets stock it; however, it can easily be bought online. Pyrocalm Control comes in two box sizes with 7 or 14 tablets.

6. Pantoloc Control (Pantoprazole)

Availability: Pharmacy only medication  Dose: One tablet per day (20mg of pantoprazole daily)

The last on the list of Ranitidine alternative drugs is Pantoloc. This product contains 20mg of pantoprazole per tablet, another drug classified as PPI.

Not all pharmacies stock Pantoloc.

A quick search online revealed that limited websites stock Pantoloc. Pantoloc Control is sold in two box sizes of 7 and 14 tablets.

7. Antacids

Antacids are less effective in the management of acid reflux as compared to PPIs discussed in previous paragraphs. Antacids do not stop the production of gastric acid but neutralize it in the stomach.  Antacids can provide fast and short-term relief from heartburn symptoms.

Antacid can be purchased from supermarkets, pharmacies, and retail outlets. There is a number of antacid products available on the market. Antacid can be bought as chewable tablets, a liquid formulation, or sachets.

Popular brands of antacid products include:

  • Gaviscon range of antacid products
  • Rennie range of heartburn and indigestion chewable tablets
  • Tums chewable tablets
  • Peptic liquid

You can learn more about the availability of different antacids in related posts: 16 Best Gaviscon Alternative Products.

Ranitidine Alternative Drugs: Prescription-Only Medicines

Patients who used Ranitidine on prescription can be easily switched to alternative treatment with PPI unless contraindicated. In practice, some patients are treated with both PPIs and Ranitidine at the same time and continuously, although concomitant use of both drugs has questionable effectiveness.

NICE guidance on the management of dyspepsia recommends short use only (14 days intermittently) of Ranitidine and PPI at the same time (NICE, 2017). Patients who are currently treated with Ranitidine are advised to speak to their GP about the alternative treatment due to ongoing shortages of Ranitidine in the UK.

Prescribed H2-receptor Antagonists Alternative To Ranitidine

There are few options when it comes to H2-receptor antagonists available on prescription, including:

  • 8. Famotidine
  • 9. Cimetidine
  • 10. Nizatidine

All of the above drugs are not commonly prescribed. At the point of writing of this post, all above H2-receptor antagonists are out of stock, most likely due to increased demand caused by supply problems with Ranitidine.

To give you a rough idea, in the last 12 months, over 6.1 mln Ranitidine prescriptions were issued.

During the same period (OpenPrescribing.net, 2019):

  • Famotidine was prescribed 13,716 times
  • Nizatidine was prescribed 17,866 times
  • Cimetidine was prescribed 43,206 times

Cimetidine is not commonly prescribed as it affects how other drugs are absorbed (how much drug gets into the body), their metabolism (how much medication is changed into the active form in the body), and elimination (how much drug leaves the body).

With a number of potential interactions with other drugs, cimetidine became an obsolete choice in the management of gastro-oesophageal reflux disease (GORD).

Alternative Options For Prescription-only Proton Pump Inhibitors

11. Omeprazole

Omeprazole is the most commonly used PPI in the management of dyspepsia/GORD in the UK. It is also one of the most prescribed drugs in the UK. Prescribed omeprazole is available in different formulations, including:

  • Omeprazole gastro-resistant tablets
  • Omeprazole gastro-resistant capsules
  • Omeprazole dispersible tablets
  • Omeprazole liquid

Tablet and capsule forms of omeprazole exist in the following strengths: 10mg, 20mg, and 40mg.

Omeprazole liquid is classified as a special product in the UK. It is made on an individual basis for each patient, usually children, but also patients with swallowing difficulties.

To learn more about omeprazole liquid, please read my separate post on this product. Omeprazole became the first choice when PPIs are considered in the treatment due to the low cost and effectiveness of the treatment.

12. Lansoprazole

Lansoprazole is the second most prescribed PPI in the UK. Lansoprazole is available in the form of 15mg and 30mg capsules and orodispersible tablets.

When prescribed, orodispersible formulations (brand name: Zoton FasTab) are commonly used in patients with swallowing difficulties or in children. Orodispersible tablets dissolve in the mouth when placed on the tongue.

13. Esomeprazole

Esomeprazole comes in the form of capsules and tablets, available as 20mg and 40mg preparations. Esomeprazole can be prescribed as a generic medication or as a branded drug called Nexium. The latter is not commonly prescribed due to the big price difference between generic versions of esomeprazole and Nexium.

14. Pantoprazole

Pantoprazole on prescription comes only in the form of tablets. 20mg and 40mg of pantoprazole drug are available. Pantoprazole is not commonly prescribed in the NHS.

15. Rabeprazole

Similar to pantoprazole, rabeprazole is not commonly prescribed in the UK. Rabeprazole comes in form 10mg and 20mg gastro-resistant tablets.

Which PPI is the best?

There is no evidence to suggest one PPI is better than another. However, when PPIs are prescribed for treatment of GORD, for example, patients may be switched between PPIs if one fails to produce a satisfactory response (NICE, 2017). Omeprazole and lansoprazole are the most prescribed PPIs in the UK.

Final Words From Druggist

When it comes to short-term management of heartburn / acid reflux, patients have a good choice of drugs, which are available without a prescription.

Five different proton pump inhibitors are available over the counter from a pharmacy, with three being licensed as general sale items, which can be purchased from any retail outlet.

Patients who have been experiencing symptoms of heartburn for longer than two weeks (despite PPI treatment) should speak to their GP. Additional symptoms highlighted by manufacturers of PPIs that needed a referral to include:

  • As weight loss (for no reason)
  • Repeated episodes of sickness
  • Difficulties in swallowing
  • Blood present in the vomit or feces
  • Repeated episodes of indigestion
  • Presence of new or recently changed symptoms in patients who are 55 and over
  • Presence of pain or lump in the stomach
  • Fong, S. and Dunn, J., 2013. Dyspepsia: alarm symptoms, investigation and management. Prescriber24(7), pp.13-26. NICE (2017).  Dyspepsia - proven GORD. Available at: https://wchh.onlinelibrary.wiley.com/doi/abs/10.1002/psb.1035
  • Martin, R.M., Lim, A.G., Kerry, S.M. and Hilton, S.R., 1998. Trends in prescribing H2-receptor antagonists and proton pump inhibitors in primary care. Alimentary pharmacology & therapeutics12(8), pp.797-805. OpenPrescribing.net (2019), EBM DataLab, University of Oxford, 2017. Prescribing information for H2-receptors anatagonist. Available at: https://europepmc.org/article/med/9726394 Accessed on 06/02/2020