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Does Ranitidine Cause Cancer?

Does Ranidine Cause Cancer

What is Ranitidine?

Ranitidine is a drug that is primarily used for the treatment of ulcers of the stomach and the intestines. It was introduced in 1981. Zantac is the brand name under which Ranitidine is sold in the market.

It also acts as a shield in protecting the body from recurrent ulcers. It belongs to the drug class called Histamine-2 blockers. Ranitidine is an oral medication that can be taken with or without food.

Uses of Ranitidine:

Ranitidine is also used for stomach and throat problems such as Gastroesophageal Reflux Disease (GERD) and Erosive Esophagitis, causing heartburn and esophagus injury. It helps balance conditions such as Zollinger-Ellison syndrome, in which the stomach produces too much acid. It also gives relief from the symptoms such as cough and difficulty in swallowing.

Dosage:

The dosage depends upon the medical condition and the response of the individual to the treatment. It is generally recommended to take once or twice a day but can be prescribed in 4 doses daily, depending on the situation. Regular medication will provide better results.

Ranitidine Dosage

Side Effects:

side effects of Ranitidine

 

Common side effects of Ranitidine can be

1. Constipation
2. Diarrhea
3. Nausea
4. Vomiting

Serious side effects which require emergency doctor consultation and termination of medication:

1. Allergic reactions
2. Blurred vision
3. Mental changes
4. Severe stomach pain
5. Rashes and itching
6. Trouble in breathing
7. Signs of infection
8. Tiredness
9. Change in heartbeats
10. Yellowing of eyes and skin
11. Dark urine.

Precautions and Interactions:

Before taking Ranitidine, consult your doctor if you have:

1. Other allergies or allergies to H2 blocker
2. Blood disorders.
3. Immune system problems.
4. Kidney and liver problems.
5. Lungs disease.
6. Stomach disorders.
7. Diabetes.

Ranitidine can have interactions with:

1. Medicines that have Ranitidine or other H2 blockers.
2. Herbal products.
3. Azole antifungals such as Ketoconazole and Itraconazole.

Ranitidine and Cancer:

Ranitidine-and-Cancer

Ranitidine is used to treat stomach ulcers and heartburns. Yes, Ranitidine has its advantages. It also has a major disadvantage. Have you heard of the term Zantac Cancer? Zantac is associated with cancer, not as a medication but being one of the causes. So let us find out more about Zantac Cancer.

Ranitidine is used to treat stomach ulcers and heartburns. Yes, Ranitidine has its advantages. It also has a major disadvantage. Have you heard of the term Zantac Cancer? Zantac is associated with cancer, not as a medication but being one of the causes. So let us find out more about Zantac Cancer.

According to the study conducted by the researchers, Ranitidine contains NDMA is the primary chemical that is known as the reason for causing cancer in human beings.

What is NDMA?

NDMA is known as N- Nitrosodimethylamine. It can be formed during the preparation of food, prominently fish and meat, as they have sodium nitrate acting as a preservative. It can also be found in vegetables, cheese, fruits, beer, etc.

It is one of the most potent animal carcinogens. The research done on the rodents showed consistent carcinogenic effects and an increase in renal tumors and hepatic rate.
According to the US Food and Drug Administration, the levels of N-Nitrosodimethylamine increase with time and temperature. NDMA is formed by the chemicals Dimethylamine (DMA) and Nitrite, which are present in Ranitidine.

via GIPHY

Cancers caused due to Ranitidine:

Zantac contains NDMA in high quantities that leads to Zantac Cancer. Thus, it contributes to various types of cancers in our body and can be fatal.

Following are the types of cancers caused due to Ranitidine:
1. Liver Cancer
2. Bladder Cancer
3. Breast Cancer
4. Pancreatic Cancer
5. Prostate Cancer
6. Throat and Nasal Cancer
7. Stomach and Intestinal Cancer
8. Colorectal Cancer
9. Leukemia
10. Kidney Cancer

Studies indicate that a high amount of NDMA is produced when Ranitidine gets mixed with the digestion process stimulating chemicals like gastric fluid and sodium nitrates. The quantity of NDMA in Ranitidine is much higher than that present in food. It significantly increases the amount of NDMA present in the urinary tracts.

Conclusion:

As Ranitidine contains NDMA, it poses a significant threat to the human body by causing cancer. It causes severe damages to the body and the other organs and disturbs the proper functioning of different body systems.

No adequate method is there to determine the quality of risk involved in taking Ranitidine, but the higher the dose of Ranitidine, the higher the risk of getting diagnosed with cancer due to the increased exposure to NDMA. Also, the amount of NDMA increases in Ranitidine when it is out in temperature higher than room temperature.

Many Drug manufacturers have recalled the Ranitidine products and voluntarily decided to remove them as they threaten human life. Multiple voluntary recalls took place to prevent people from consuming it.

But there are alternatives for Ranitidine available such as Esomeprazole and Omeprazole which don’t pose any risk for humans.

Reference:

1. Vial, T., Goubier, C., Bergeret, A., Cabrera, F., Evreux, J.C. and Descotes, J., 1991. Side effects of ranitidine. Drug safety, 6(2), pp.94-117. Available at https://link.springer.com/article/10.2165/00002018-199106020-00002 Accessed on 08 November 2021.

2. Miller, A.K., DiCicco, R.A. and Freed, M.I., 2002. The effect of ranitidine on the pharmacokinetics of rosiglitazone in healthy adult male volunteers. Clinical therapeutics, 24(7), pp.1062-1071. Available at https://www.sciencedirect.com/science/article/abs/pii/S0149291802800194 Accessed on 08 November 2021.

3. Brogden, R.N., Carmine, A.A., Heel, R.C., Speight, T.M. and Avery, G.S., 1982. Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases. Drugs, 24(4), pp.267-303. Available at https://link.springer.com/article/10.2165/00003495-198224040-00002 Accessed on 08 November 2021.

4. Long Mahase, E., 2019. FDA recalls ranitidine medicines over potential cancer causing impurity. Available at https://www.bmj.com/content/367/bmj.l5832 Accessed on 08 November 2021.