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Ranitidine vs Omeprazole: Which Drug Is Better?


After my recent post on Omeprazole’s alternative drugs, I want to stay on the subject of gastro-oesophageal reflux disease (GORD) and its treatment.

How The Mechanism Of Action Differs Between Ranitidine & Omeprazole?

Ranitidine and Omeprazole belong to different classes of drugs, both used in the treatment of heartburn/indigestion. Ranitidine is classified as an h2 receptor antagonist, commonly named h2 blockers. Omeprazole belongs to a group of drugs called proton pump inhibitors (PPIs).

The differences between both drugs come from a distinct mechanism of action on stomach acid suppression. Stomach acid is produced in response to the activation of one of three receptors located on cells in the lining of the stomach. One type of these receptors (h2 receptors) can be blocked by Ranitidine, preventing the initial production of the acid via this one route.

PPIs such as Omeprazole, on the other hand, block the proton pump, which is responsible for the secretion of the stomach acid in the final part of its production.

Watch the video below to get a more detailed explanation of the mechanism of action of both drugs.

Quick FAQ

What is the best alternative to Omeprazole?
Alternatives to PPIs
• Cimetidine (Tagamet)
• Ranitidine (Zantac)
• Nizatidine (Axid)
• Famotidine (Pepcid)

Ranitidine vs Omeprazole: The Effectiveness

Quick FAQ

Is Ranitidine banned?
Ranitidine is not banned in the UK, however, there is an ongoing investigation to its safety, due to contamination with a 'carcinogenic' compound called NDMA.

A number of studies and clinical trials confirmed that PPIs (Omeprazole) is more effective in the reduction of acid production than H2-blockers (Ranitidine). PPIs are more effective in the reduction of acid production because acid secretion is stopped in the last stage of acid production.

Ranitidine vs Omeprazole: Safety And Common Side Effects

Ranitidine common side effects

Ranitidine has a very good side effect profile with no common (1 in 10) side effects listed.

Omeprazole common side effects

The use of Omeprazole is associated with a number of common side effects, including:

Ranitidine vs Omeprazole

  • Headaches
  • Abdominal pain
  • Constipation
  • Diarrhoea
  • Flatulence
  • Nausea/vomiting

Long term use of Omeprazole (or other PPIs) may increase (BNF,n.d):
Risk of bone fractures (high doses are taken mainly by the elderly population)
Risk of gastrointestinal infections

In 2019 number of Ranitidine products were recalled from UK pharmacies and supermarkets due to possible contamination with N-Nitrosodimethylamine (NDMA), a probable human carcinogen. Recalled products included over-the-counter and prescription-only Ranitidine. You can read more about it in my separate post: Ranitidine and Cancer: What is the risk?

In 2017 a research paper was published in Gut magazine associating the use of PPIs with increased risk of gastric cancer development. This study looked at patients from Hong Kong who were treated for Helicobacter pylori infection.

H. pylori infection can cause recurring episodes of indigestion. Treatment of confirmed H. pylori infection involves taking a short course of 2 different antibiotics with a PPI, such as Omeprazole (triple therapy).

Although eradication of H. pylori infection reduces the risk of stomach cancer development, the above study found that taking PPIs more than doubled this risk. The average time that PPIs were taken by patients was three years after the triple therapy.

All patients had a long history of gastritis, which is the inflammation of the stomach lining (BMJ, n.d.). This risk is further increased with the duration of treatment and dose frequency after the triple therapy.

The same study concluded that taking H2 blockers, such as Ranitidine, is not associated with an increased risk of stomach cancer development.

Quick FAQ

Can Omeprazole cause chest tightness?
Rashes, hives, itching, red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; difficulty breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat are all symptoms of an allergic response.

Can Omeprazole cause anxiety?

More than 300 senior Italians took part in the study, answering questions about their mood and whether or not they take proton-pump inhibitors like omeprazole (Prilosec). PPI users were nearly twice as likely as non-users to experience depression or anxiety.

Use Of Ranitidine & Omeprazole At The Same Time

Headaches Abdominal pain Constipation Diarrhoea Flatulence Nausea/vomiting

The NICE guideline recommends the use of H2-blocker (Ranitidine) at night in addition to PPIs (Omeprazole) for people with persistent or recurrent symptoms of GORD or confirmed oesophagitis (inflammation of the tube that connects the stomach with your mouth).

This should be prescribed on a short-term basis (for example, for a 2-week course intermittently).) and when patients experience symptoms at night, subject to clinical judgment by a GP (NICE, 2017).

NICE suggests additional use of H2 blockers such as Ranitidine is likely to be increasingly ineffective, patients may not benefit from combination treatment, and within weeks night-time symptoms may come back (ibid).

Can You Take Ranitidine And Omeprazole Together?

Based on clinical judgment, the GP may decide to prescribe both Ranitidine and Omeprazole. Pharmacologically, Omeprazole overlaps the mechanism of action of Ranitidine.

Based on this and as it is suggested by the NICE guidelines addition of Ranitidine in the treatment of persistent GORD together with Omeprazole may bring short benefits, if any.

Can You Take Ranitidine And Omeprazole Together


Other strategies on the management of GORD need to be explored, including doubling up the dose or switching from daily to twice-daily dosing, or switching to a different PPI.

Current evidence on the use of these strategies, however, is limited.


To sum up, Omeprazole is more effective in controlling stomach acid production and the management of GORD symptoms than Ranitidine. PPIs are associated with some common side effects; long-term use of PPIs may increase the risk of infections and bone fractures.

In contrast, H2 blockers have a better safety profile; however, they are less effective in reducing stomach acid production.

Quick FAQ

Which is better ranitidine or omeprazole?
Based on the pharmacology of both drugs omeprazole is better than ranitidine. Omeprazole and other Proton Pubm Inhibitors (PPIs) stop the last step of stomach acid production, whereas ranitidine just one patch of acid production.
What is the difference between omeprazole and ranitidine?
Omeprazole belongs to a group of drugs called Proton Pubm Inhibitors (PPIs). Ranitidine belongs to a class of drugs called H2-receptor antagonists. The main difference between omeprazole and ranitidine is how both drugs suppress stomach acid production. Omeprazole act on the proton pump, which is responsible for the last step of stomach acid production, whereas ranitidine stops one path of stomach acid production, by acting on h-2 receptors.
What is equivalent to ranitidine?
In the UK, other h2-receptor antagonists include famotidine, cimetidine and nizatidine. All drugs belong to the same class of medicines, hence may be called equivalent to each other.
Is ranitidine banned?
Ranitidine is not banned in the UK, however, there is an ongoing investigation to its safety, due to contamination with a 'carcinogenic' compound called NDMA.