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Saxenda Review – Effectiveness Of New Weight Loss Drug.

Saxenda Review - Effectiveness Of New Weight Loss Drug

Saxenda (Liraglutide) is one of two drugs licensed in the UK for weight loss. Saxenda is the brand name of the drug Liraglutide, also known under the branded name of Victoza, which has been used in the treatment of type 2 diabetes in the UK since 2009. The focus of Saxenda review is the use of Liraglutide in weight loss; however other areas are discussed, including:

Quick FAQ

How long do you think it will take you to notice the benefits after using Saxenda?
Within two weeks of using Saxenda, weight reduction usually begins (Liraglutide)

Saxenda Review: What Is The License In The UK

weight loss

Saxenda (Liraglutide) was introduced to the UK in 2017. It is licensed as part of a reduced-calorie diet and increased physical activity in obese patients with:

  • BMI of more than 30 (obese) or
  • BMI of less than 30 but more than 27 (overweight) who have weight-related conditions such as prediabetes, diabetes, hypertension, dyslipidemia (for example, high cholesterol level)

Additionally, treatment will be discontinued if a satisfactory body weight loss is not achieved (reduction by 5% of initial body weight) in 12 weeks.

Saxenda Review Of Mechanism Of Action?

Without going deep into the science, Saxenda’s mechanism of action is described as hormonal. Saxenda mimics the movements of the GLP-1 hormone (found in our body) to decrease appetite and increase satiety (Sexandapro.com, ND), which contributes to a decrease in calorie intake and consequent weight loss.

Saxenda review of the licensed dose in weight management

Patients who use Saxenda star on a dose of 0.6mg once daily. It is recommended to increase the dose in intervals of at least one week to a maximum dose of 3mg daily. The dose should be increased by 0.6mg at least seven-day intervals.

Saxenda comes in the form of a prefilled, multi-dose pen. Saxenda is injected daily into one of the following areas:

  • Stomach area
  • Upper leg (thigh), or
  • Upper arm

The video below demonstrates how the Saxenda pen is used.

Saxenda for weight loss vs. Victoza for type 2 diabetes, what is the difference?

Both prefilled, same size pens contain the active drug – Liraglutide at 6mg in 1ml. Excipients present in Saxenda and Victoza are almost the same, except for a couple of ‘inactive’ ingredients used in the formulation of Saxenda. The following are the main differences/similarities between both products:



Licensed indication Weight management (weight loss) in conjunction with hypocaloric diet and exercise in obese patients (BMI over 30) or patients with BMI over 27 with other health conditions. Management of type 2 diabetes in conjunction with diet and exercise. Victoza can be used on its own where metformin is contraindicated or intolerant or as a combination therapy with other antidiabetic drugs.
Age For adults only Adults and children over ten years of age
Dose Starting dose of 0.6mg increased to a maximum of 3mg daily. Starting dose of 0.6mg increased to a maximum of 1.8mg. Higher doses are not recommended.
Side effects Similar for both products. Refer to the product information leaflet for more details.
Cost for private patients Around £75 per pen. Around £50 per pen.
Can you get it on NHS? Yes, however unlikely. Yes.

Saxenda review of effectiveness?

Main studies: summary (NICE, 2017)

The main evidence behind the effectiveness of Saxenda comes from 4 clinical trials. Patients who used Saxenda were obese or overweight and had co-morbidity such as hypertension.

During the trials, there was a significant difference in weight loss between patients who used Saxenda and patients who used a placebo product (a product that did not contain the active drug).

All patients who participated in clinical trials received lifestyle interventions for weight loss, such as a reduced-calorie diet and increased exercise.

Across all studies (duration between 32-160 weeks), the estimated weight loss was between 5.4% and 4% of body weight (NICE, 2017).

However, many patients regained their weight after stopping the treatment. Overall, more patients who received Saxenda treatment left clinical trials due to side effects experienced (9.2-13%) versus 3.3%-6% who received placebo treatment (ibid).

Weight-loss outcomes: summary study 1 (Pi-Sunyer et al., 2015)

  • A 56-week study in obese patients (BMI over 30) or patients with BMI 0ver 27 with other conditions such as high cholesterol or blood pressure levels
  • 3731 patients
  • Placebo-controlled: some patients used products with no active drug
  • Dose of Saxenda used: 3mg once daily with advice (counseling) on lifestyle changes.
  • Outcomes:
  • 63.2% of patients who used Saxenda lost 5% or more of body weight as compared to 27.1% of the placebo patient group
  • 33.1% of patients on Saxenda lost 10% or more of their body weight as compared to 10.6% on placebo treatment
  • The most common reported side effects were nausea and diarrhea
  • Serious side effects were experienced by 6.2% of patients who used Saxenda versus 5% of patients on placebo

Quick FAQ

Does Saxenda stop working after a while?
These drugs do not stop functioning, but they may appear ineffective in suppressing appetite, or your weight-loss efforts may have slowed, and you may even be gaining weight.

Study 2 (Le Roux et al., 2017):

  • A three-year study in obese patients with prediabetes
  • 2254 participants who received treatment with Saxenda (3mg once daily) or placebo in conjunction with a reduced-calorie diet and increased exercise
  • 2% of patients treated with Saxenda developed diabetes as compared to 6% who used placebo treatment
  • Overall, Saxenda may reduce the risk of diabetes development in obese or prediabetic patients

Saxenda Review Of Possible Side Effects and Warnings 

Like with all drugs, the use of Saxenda for weight loss comes with a risk of side effects.

stomach pain

Widespread side effects experienced by 10% or more patients include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation

Additionally, there is a number of common side effects, including:

  • Dry mouth
  • Dizziness
  • Hypoglycemia (low sugar level)
  • Dyspepsia and Gastro-oesophageal reflux disease (GORD)
  • Fatigue

Please note this is not an exhaustive list. For a list of all side effects and warnings, read the product information leaflet, which can be found online.

Quick FAQ

What happens if you Overdose on Saxenda
Call your healthcare practitioner straight away if you take too much Saxenda. Saxenda overdose can result in extreme nausea and vomiting.

Saxenda cancer risk

One of the first warnings that pop up when visiting www.saxendapro.com is important safety information about the risks of thyroid C-cell tumors (Saxendapo.com, ND):

  • Liraglutide causes dose-dependent and treatment duration-dependent thyroid C-cell tumors in both rats and mice
  • It is not known if Saxenda has the same effect on humans
  • Patients should be informed about the risk and possible symptoms of thyroid tumors

Other warnings:

  • Acute pancreatitis including fatal and non-fatal hemorrhagic or necrotizing pancreatitis (death of pancreas due to lack of blood supply)
  • Acute gallbladder disease
  • Risk of hypoglycemia when used with other ant-diabetic drugs
  • Heart rate increase
  • Renal impairment
  • Hypersensitivity reactions
  • Suicidal behaviors:
  • During a clinical trial in humans, 9 of 3384 patients (0.3%) treated with Saxenda reported suicidal thoughts (0.1% for placebo), with one attempted suicide.

For more information, visit the above warning visit the SaxendaPro website.

Saxenda cost

Saxenda cost per pen

Saxenda cost varies between pharmacies. Saxenda can be purchased online with prices of around £75 per pen.

Saxenda monthly cost

  • Each Saxenda pen contains 18mg of active drug Liraglutide in 3ml of solution
  • If the maximum daily dose were used, 3mg, for example, one pen would last six days; therefore, the patient would require five pens each month to deliver a maximum daily dose of 3mg.
  • Based on this monthly cost of Saxenda would equal £375

Where to buy Saxenda?

Saxenda can be purchased online from registered pharmacies. When Saxenda is purchased online, normally, patients need to answer a number of questions about their health to assess the product’s suitability.

Patients who have Saxenda prescribed privately can use any conventional pharmacy to process a Saxenda prescription. The prices in high street pharmacies may vary; therefore, it is recommended to call/visit a few pharmacies to get the best deal.

Saxenda weight loss on NHS?

Saxenda can be prescribed in the UK. Saxenda is not commonly prescribed in the UK. Prescribing information available on OpenPrescibing.net shows that it was only prescribed 13 times in January 2019 (an increase from 7 in December 2018).

Today, Saxenda use in NHS is minimal and not included in NICE recommendations on identifying, assessing, and managing obesity. The only current treatment option recommended by this guide is Orlistat.

European Medicine Agency, which publishes reports for each medication that receives marketing authorization, noted that it is ‘unlikely that any potential weight loss achieved with liraglutide’ will continue after the treatment is stopped.

Saxenda Review Summary

Saxenda offers an exciting approach to weight loss; however, there are many possible common, widespread side effects. NHS and private treatment carry a high price tag for NHS and private patients, making it almost not affordable.

Obese patients may consider other options, such as treatment with Orlistat, which is taken orally. The effectiveness of Orlistat in weight loss is covered in a separate post, Orlistat review: Can you achieve a weight loss? By far, physical exercise and a well-balanced diet are the most effective weight loss.

  • Le Roux Carel W., Arne Astrup,Ken Fujioka, Frank Greenway, David C W Lau, Luc Van Gaal, Rafael Violante Ortiz, John P H Wilding, Trine V Skjøth, Linda Shapiro Manning, Xavier Pi-Sunyer, Andreas Hamann, Alain Barakat, Matthias Blüher, Thomas Linn, Andrea Mölle et al. (2017). 3 years of Liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Available at: https://doi.org/10.1016/S0140-6736(17)30069-7 Accessed on 14/12/2019
  • Pi-Sunyer, Xavier and Astrup, Arne and Fujioka, Ken and Greenway, Frank and Halpern, Alfredo and Krempf, Michel and Lau, David C.W. and le Roux, Carel W. and Violante Ortiz, Rafael and Jensen, Christine Bjørn and Wilding, John P.H. (2015). A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. Available at: https://doi.org/10.1056/NEJMoa1411892 Accessed on 14/12/2019