Druggist Menu
Post Highlights

Can Sertraline Help You For Premature Ejaculation?

Sertraline For Premature Ejaculation

Premature ejaculation (PE) is a common problem that many men go through. It is estimated that 1 out of 3 men experience PE at some point in their lives. Premature ejaculation may affect a man’s mental health, self-esteem, confidence and affect their relationships. However, due to modern technology and scientific advancements, few medications are available that treat or help with premature ejaculation. Sertraline or Zoloft is an example of one such drug.

Sertraline, commonly known as Zoloft, is a common antidepressant. This medication is a selective serotonin reuptake inhibitor or SSRI. Serotonin is a feel-good hormone that is responsible for our well-being and happiness. Thus, it is essential to balance this hormone well, and Sertraline helps with that.

Provided the available online information, we have mentioned the use of Sertraline for Premature ejaculation (PE) in this article. However, let us understand more about Sertraline and its use to treat premature ejaculation.

Can I take Sertraline for Premature Ejaculation?

Yes, you can use Sertraline for Premature ejaculation off-label. This medication is typically used for depression, OCD, PTSD, and other social anxiety disorders. However, it is also used for PE without prescription. Premature ejaculation is when a person ejaculates quickly with very little sexual stimulation. PE can happen due to psychological or physical conditions or both. It is not easy for a person to deal with the after-effects of PE, and it can take a toll on their mental health, relationships, self, and self-confidence. Sertraline and other SSRIs help this condition by elevating a persons’ mood, drive, confidence, and mental well-being. Using Sertraline may directly affect a person mentally, increasing the time for ejaculation when sexually stimulated. A balance of psychological and physical health is essential to living a healthy and satisfactory life.

Sertraline Study

Published in The Journal of Urology on the use of Sertraline for Premature ejaculation. It was a single-blind placebo-controlled crossover study. The study was conducted on 37 potent males between the ages of  19 to 70 years old who were either married or were in a long-term relationship. All these men suffering from premature ejaculation were given a dose of 50 mg of Sertraline. The study concluded with a positive outcome of Sertraline in treating premature ejaculation with little to no side effects.

Quick FAQ

Which pills work best for premature ejaculation?
SSRIs such as Lexapro, Prozac, Zoloft (Sertraline) are known to work effectively to treat premature ejaculation.

Dosage Of Sertraline For PE

The dosage for premature ejaculation depends. A typical Sertraline dose of 25 mg is often used to treat PE. The dosage can be 50 mg, depending on the severity of the issue. However, the amount should not exceed 200 mg per day.

Sertraline can be taken with food as well as on an empty stomach.

Quick FAQ

Is 50 mg of Sertraline too strong?
Taking 50 mg of Sertraline is highly unlikely to cause problems. This dosage is optimal for therapeutic use.

How Long Does It Take For Sertraline to Work For PE?

It takes about four weeks for Sertraline to work for premature ejaculation. Furthermore, it takes the same amount of time to treat other conditions.

What If You Miss A Dose?

It is essential to take the dosage as prescribed by your healthcare professional. If you miss a dose, do not take two doses together simultaneously. You can skip a dose if it’s close to the time of your next dose. Follow the prescription or your doctor’s advice to avoid overdosing on Sertraline.

What If You Overdose?

You should immediately call the emergency helpline number for your respective area. For example, 999 in the UK and 911 in the US are their respective helpline numbers. If it’s not too severe, you can consult your doctor as soon as possible and always try to remember the dosage as advised.

Who Should Not Take Sertraline?

You must tell your doctor if you are allergic to Sertraline (Zoloft). It is also necessary that you inform your doctor about your medical history and pre-existing medical conditions before starting a new treatment.

  • The use of Sertraline must be taken with extra caution by the people suffering from these conditions:
  • People who have suicidal tendencies
  • Low amount of sodium in the blood
  • Closed-angle glaucoma
  • People who have poor metabolism
  • People who are prone to stomach or esophagus bleeding

Other conditions not mentioned in this article can worsen by using Sertraline.

Sertraline must not be used as an alternative for Viagra as it does not work like that. It is used only for depression disorders, OCD, and premature ejaculation. Not to be confused as a sexual stimulant.

Avoid These While On Sertraline

Getting intoxicated with alcohol is not advised when using Sertraline. That may cause an increase in dizziness and also causes a lack of motor functioning.

Try to avoid driving your car or operating heavy machinery, as your reaction time may be delayed while using this medication. When starting a new drug, always take extra precautions and consult your doctor if you are confused.

Interactions Of Sertraline With Other Drugs

It is not possible to mention all drug interactions with Sertraline. However, we know about 630 drugs to interact with Sertraline.
Some commonly used drugs known to interact with Sertraline are:

  • Adderall
  • Aspirin
  • Fish oil
  • Benadryl
  • Tylenol
  • Xanax

Inform your doctor if you are already on medications known to interact with Sertraline.

Possible Side Effects

Like most medications, Sertraline use can also cause side effects in some people.

Here are some of them:

  • Nausea, diarrhea, dizziness, and headaches

These are among the most common side effects that can significantly reduce the quality of everyday life.

  • Seizure

Seizures can occur to some people using this medication that last up to 30 seconds to 2 minutes.

  • Allergic reaction to Sertraline

Allergic reactions such as skin rash, hives, swelling of the face or lips can occur using Sertraline. Symptoms can last for about 2 to 4 weeks.

  • Changes in the vision

Using Sertraline can cause blurred vision that may last for a few weeks after starting treatment.

  • Extreme behavior changes

Some people may suffer from drastic behavior changes such as extreme irritability or happiness. After a week or two, these side effects tend to go away due to the body’s adaptability to the medicine.

  • Indigestion

Indigestions usually last for a few days or weeks and go away on their own if it’s mild.

  • Unusual sweating

Some people suffering from excessive sweating need a few days to get back to normal, while others take weeks depending on their body’s adaptability to the medication.

This medication might also cause sexual problems in some people- however, it is an infrequent side effect. We advise you to consult your doctor if you have any of the previously mentioned side effects or unusual symptoms.

Quick FAQ

Can Sertraline affect male hormones?
Yes, SSRIs have shown hormonal disruption in men with lowered testosterone levels in some cases.


Sertraline is a widely prescribed medication with a low risk of side effects. Along with depression and OCD, this medication is also known to treat premature ejaculation. You can use this drug for its immense benefits on this condition and added mental health benefits. It is best to see a doctor for any doubts or issues to know what’s best for your specific situation.