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Sominex Review From Expert and About Effectiveness

Sominex Review

An estimated 9 million people in the United States use sleeping pills. That is about 4% of the total population of the country. Sominex, which has the medication diphenhydramine, is widely used in the US. Diphenhydramine, the active ingredient in Sominex, was first made by George Rieveschl and was commercially available in 1946.

Sominex (diphenhydramine) is an antihistamine medicine. It comprises ethanolamines and works by inhibiting histamine H1 and muscarinic cholinergic receptors. It’s best to take Sominex 30 minutes before bedtime, especially for Insomnia. In the UK, Sominex has (promethazine) as an active ingredient and an antihistamine.

Severe allergic reactions, anaphylaxis, motion sickness, and extrapyramidal symptoms can all be treated with Sominex. Sominex is often used to treat hay fever, allergies, and the common cold, which produce red, irritated, itchy, watery eyes, sneezing, and a runny nose. Sominex also works against cough due to airway irritation or slight throat discomfort. Sominex can also be used to treat sleeplessness and to prevent and treat motion sickness. It manages abnormal movements in patients with early-stage parkinsonian syndrome or movement problems.

Pros And Cons Of Sominex


  • Sominex can be useful as a last resort drug that is more likely to help you fall asleep.
  • Sominex would solely target your sleep problem and enhance the chances of quality sleep.
  • It is very efficient in treating your allergy symptoms.
  • This drug can also treat motion sickness and alleviate Parkinson’s disease symptoms.


  • You could develop a tolerance that could result in the low efficiency of the drug.
  • Using Sominex could result in severe side effects.
  • Sominex is only meant for the treatment of short-term symptoms.

Sominex Ingredients:

Active Ingredients:

  • Diphenhydramine
  • HCI 25 mg

Inactive Ingredients:

  • Croscarmellose sodium
  • Dicalcium phosphate
  • FD&C blue no.1 lake
  • Hypromellose,
  • lactose
  • Magnesium stearate
  • Microcrystalline cellulose
  • Mineral oil
  • Silica
  • Stearic acid
  • Talc
  • Titanium dioxide
  • Triacetin

Additional Information:

  • Each tablet contains 10mg of calcium
  • Store Sominex at a room temperature of 20°-25°C (68°-77°F)

Benefits Of Using Sominex:

Sominex is an antihistamine used to treat allergy, hay fever, and common cold symptoms. This medication prevents multiple issues such as rash, itching, watery eyes, irritated eyes/nose/throat, cough, runny nose, and sneezing. It’s also used to prevent and treat motion sickness symptoms like nausea, vomiting, and dizziness. Sominex gives relief to your allergy symptoms and also helps in aiding sleep. Sominex has many benefits and can be a multipurpose medicine too. You can ask your doctor or pharmacist about the other advantages of using Sominex.

Brand Overview

Sominex is an antihistamine that has diphenhydramine as an active ingredient. In the United States, Sominex is marketed by Prestige Brands. Diphenhydramine is also marketed in Canada as an otc sleeping pill under the same name. The FDA has not evaluated this product yet. Sominex is available over-the-counter and does not require a prescription.

Sominex Reviews: What Do Customers Think?

“I think many people who are reading this might have a similar story. I couldn’t sleep for a long time as I suffered from Insomnia. One day I decided to visit a doctor, and he suggested I take Sominex. Well, one thing I can say about this medicine is that it worked for me. I am delighted I found Sominex.” -Steven.

“I’ve been using Sominex for a long time now. I can say that I’m not as sleepy in the mornings as I used to be. Since I started using this medicine, I’ve been sleeping properly. I usually order it online as it’s not always available at my local store.” -Neil.

“I use Sominex when I have a cold and am unable to sleep. It works for me and helps me relieve common cold, plus I sleep well.” -Laura.

How Does Sominex Work?

The US version of Sominex has diphenhydramine as an active ingredient, a first-generation antihistamine. At the same time, the UK version of Sominex has promethazine as an active ingredient. Diphenhydramine works as an anti-cough medication by crossing the blood-brain barrier and suppressing the H1 CNS receptors. Furthermore, it also works against muscarinic acetylcholine receptors causing it to be used as an antiparkinson medication. While promethazine also works as an antihistamine by stopping the central and peripheral effects of H1 receptors. When Sominex blocks H1 receptors, muscarinic, and dopamine receptors, it enables the treatment of nausea and vomiting.

Possible Side Effects:

Following are the side effects of Sominex; consult a doctor if you notice any of these:

Common side effects:

  • An increase in the thickness of mucus secretions
  • Drowsiness
  • Dizziness

Infrequent Side Effects:

  • Inducing A Deep, Relaxed State

Rare Side Effects: (Severe)

  • The condition of blood where the red Blood cells burst is called hemolytic anemia
  • A blood disorder
  • Fast heartbeats
  • Low blood pressure (hypertensia – increase in blood pressure)
  • Hallucinations
  • Seizures
  • Anaphylaxis

Rare Side Effects: (Less severe)

  • Confusion
  • Nightmares
  • A migraine
  • headache
  • Blurred
  • vision
  • Ringing in the ears
  • Dryness of the nose
  • Dry mouth
  • Constipation
  • Itching

Sominex Dosage And Tips To Start:

Follow the directions mentioned on the label or as advised by your doctor. Sominex should only be used for a brief period of time until your symptoms subside. When giving Sominex to a child, always follow the directions on the medicine label. Please do not give the drug to a child solely to put them to sleep. Antihistamine misuse can result in death when abused on children. It is not advised to drink alcohol before taking Sominex as it may cause more drowsiness and sedation.

Motion Sickness:

Consume Sominex (25 mg) 30 minutes before you will
be in a condition that produces motion sickness. For the rest of the time, you’ll be experiencing motion sickness. It can be taken with meals and taken at night.

Sleeping Aid:

Take Sominex (25 mg) 30 minutes before bedtime as a sleep aid. Before swallowing it, it is advised to chew it properly.

How To Use It?

Remove an orally disintegrating tablet out of the package when you are ready to use Sominex. Let the pill dissolve in the mouth with chewing. Swallow the tablet after it melts. Avoid using Sominex for more than 2 weeks if you’re treating sleep issues. If you’re treating cold or allergy symptoms, don’t take it for more than 7 days. Follow the guidelines mentioned in the information leaflet or consult a healthcare professional if you are unsure.

What Happens If I Miss A Dose?

You would not be on a dose plan with Sominex because it is used as needed. If it’s time for your next dose, skip any missed dose. Do not take two dosages at the same time.

What Happens If I Overdose?

Vomiting, confusion, severe sleepiness, ringing in the ears, no urination, very dry eyes, mouth, dilated pupils, fast heartbeats, tremors, agitation, hallucinations, or seizure are all possible overdose symptoms.
Do seek medical help immediately if you have overdosed by consulting your doctor or calling helpline numbers. You should directly contact the emergency helpline number for your respective area. For example, 999 in the UK and 911 in the US are their respective helpline numbers. 

Is Sominex Worth It?

Sominex can be very beneficial for Insomnia. Researchers have found out that it works very well for a good night’s sleep, and after using it, people feel great in the morning and don’t feel tired in the morning. Sominex is also pretty useful to control motion sickness and manage the symptoms of allergies.


Sominex is an antihistamine that helps in the management of allergen symptoms. Sominex is also used for treating motion sickness, sleeplessness, and the symptoms of Parkinson’s disease. Sominex has different active ingredients in the US (Diphenhydramine) and UK (Promethazine). Feel free to consult your doctor before taking the medication if you are unsure or have pre-existing medical conditions.

Quick FAQ

How long does Sominex make you sleep?
This medication can make you drowsy for up to 12 hours.
Is it OK to take 2 Sominex?
Yes, but don't take more than 2 tablets at once.
Can you take Sominex with ibuprofen?
No interactions were found between both the drugs, although one should always consult your doctor before doing so.