Depression is a widespread condition in the UK, which reflects prescribing trends for antidepressant drugs. In recent years antidepressants became the fastest growing class of drugs in the UK. In 2019, four million more antidepressant items were prescribed as compared to 2018, reaching 74.4 mln prescribed items. In this post, I will be looking at the most common antidepressants in the UK. I will also discuss the rationale behind the popularity of some commonly used antidepressants in the UK.